CAJ | 학술논문

目的探讨黏蛋白1(MUC1)、黏蛋白15(MUC15)在老年甲状腺乳头状癌(PTC)患者中的表达水平及其在发病过程中的作用.方法应用免疫组织化学法检测10例腺瘤旁正常甲状腺组织、57例甲状腺乳头状癌(PTC)、14例PTC颈部淋巴结转移组织标本中MUC1、MUC15蛋白的表达水平.结果 MUC1、MUC15在甲状腺正常组织、乳头状癌组织、淋巴结转移癌组织中阳性表达率分别为40.0％、75.4％、64.3％和0、73.7％、71.4％,乳头状癌组织中MUC1阳性表达率明显高于正常甲状腺组(x2 =5.10,P=0.02).与正常甲状腺组织比较,MUC15在乳头状癌组、淋巴结转移癌组阳性表达率均显著升高(x2=12.25、19.75,均P＜ 0.05).MUC15在微小癌(肿瘤直径≤1cm)中表达明显高于其在非微小癌(肿瘤直径＞1 cm)中的表达(90.9％比62.9％,x2=5.48、p=0.02);MUC15在无淋巴结转移的癌组织中的表达明显高于伴淋巴结转移的癌组织中的表达(83.8％比55.0％,x2=5.55、P=0.02).在甲状腺乳头状癌组织中MUC1的表达与MUC15的表达呈正相关性(r=0.35,P=0.01).结论 MUC1、MUC15可能在甲状腺乳头状癌的发生中起促进作用,并存在协同作用;MUC15在甲状腺癌发生早期阶段起调控作用,可为甲状腺微小癌筛查的辅助指标之一.
목적 탐토점단백1(MUC1)、점단백15(MUC15)재노년갑상선유두상암(PTC)환자중적표체수평급기재발병과정중적작용.방법 응용면역조직화학법검측10례선류방정상갑상선조직、57례갑상선유두상암(PTC)、14례PTC경부림파결전이조직표본중MUC1、MUC15단백적표체수평.결과 MUC1、MUC15재갑상선정상조직、유두상암조직、림파결전이암조직중양성표체솔분별위40.0％、75.4％、64.3％화0、73.7％、71.4％,유두상암조직중MUC1양성표체솔명현고우정상갑상선조(x2 =5.10,P=0.02).여정상갑상선조직비교,MUC15재유두상암조、림파결전이암조양성표체솔균현저승고(x2=12.25、19.75,균P＜ 0.05).MUC15재미소암(종류직경≤1cm)중표체명현고우기재비미소암(종류직경＞1 cm)중적표체(90.9％비62.9％,x2=5.48、p=0.02);MUC15재무림파결전이적암조직중적표체명현고우반림파결전이적암조직중적표체(83.8％비55.0％,x2=5.55、P=0.02).재갑상선유두상암조직중MUC1적표체여MUC15적표체정정상관성(r=0.35,P=0.01).결론 MUC1、MUC15가능재갑상선유두상암적발생중기촉진작용,병존재협동작용;MUC15재갑상선암발생조기계단기조공작용,가위갑상선미소암사사적보조지표지일.
Objective To investigate expression levels of epithelial mucin 1 (MUC1) and epitbelial mucin15(MUC15) in elderly patients with papillary thyroid carcinoma and assess the role of MUC1 and MUC15 in the pathogenesis of thyroid papillary carcinoma.Methods Protein expression of MUC1 and MUC15 was detected by immunohistochemistry in 10 samples from normal thyroid tissue adjacent to thyroid adenoma,57 samples from papillary thyroid carcinoma (PTC),and 14 samples from PTC in neck lymph node metastasis.Results Expression rates of MUC1 in normal thyroid tissues,thyroid papillary carcinoma,and lymph node metastatic carcinoma were 40.0％,75.4％,64.3,respectively,and the rates for MUC15 were 0,73.7％,71.4％,respectively.The positive expression rate of MUC1 was higher in PTC tissues than in normal thyroid tissues (x2 =5.10,P=0.02) and,compared with normal thyroid tissues,the positive expression rate of MUC15 increased in PTC tissues and lymph node metastatic carcinoma (x2 =12.25 and 19.75,both P＜0.05)MUC15 protein expression was higher in micro-PTC (less than or equal to 1 cm in diameter) than in carcinoma larger than 1 cm in diameter (90.9％ vs.62.9,x2 =5.48,P=0.02).MUC15 expression was higher in PTC without lymph node metastasis than in PTC with lymph node metastasis (83.8％vs.55.0％,x2 =5.55,P=0.02).MUC1 expression was positively correlated with MUC15 expression in thyroid papillary carcinoma (r=0.35,P=0.01).Conclusions MUC1 and MUC15 may have synergistic effects in the initiation and progression of PTC.MUC15 may play a role in regulating tumorigenesis of thyroid papillary carcinoma in early stages and can potentially serve as a supplementary marker in the screening of micro-thyroid papillary carcinoma.