CAJ | 학술논문

目的观察老年人前列腺标本中组织学慢性炎症的病理学表现,探讨其与前列腺癌及前列腺增生的相关性.方法回顾手术切除的前列腺标本,观察不同区域的组织病理学特征,对部分病例的炎症细胞进行免疫组织化学标记CD3、CD20、CD4、CD8、CD117及CD138;标记炎症相关因子核因子-κB、环氧化酶-2、肿瘤坏死因子-α及诱异型一氧化氮合酶.结果 176例患者中,前列腺癌100例,前列腺增生76例,均检出不同程度的慢性炎症,其中轻度慢性炎为71例(40.3％),中度慢性炎为80例(45.5％),重度慢性炎为25例(14.2％).炎症细胞以CD3标记阳性的淋巴细胞为主,伴有少量的单核细胞及肥大细胞.炎症程度与前列腺癌及其分化程度、前列腺增生、局灶性萎缩及其类型、高分级上皮内瘤无相关性(均P＞0.05).COX-2的表达与炎症程度相关(P＜0.05).结论组织学的慢性炎症在老年人前列腺标本中常见,炎症程度与前列腺癌及前列腺增生无关.炎症程度与COX-2表达水平呈正相关,可能与氧化应激诱导COX-2路径活化相关.
목적 관찰노년인전렬선표본중조직학만성염증적병이학표현,탐토기여전렬선암급전렬선증생적상관성.방법 회고수술절제적전렬선표본,관찰불동구역적조직병이학특정,대부분병례적염증세포진행면역조직화학표기CD3、CD20、CD4、CD8、CD117급CD138;표기염증상관인자핵인자-κB、배양화매-2、종류배사인자-α급유이형일양화담합매.결과 176례환자중,전렬선암100례,전렬선증생76례,균검출불동정도적만성염증,기중경도만성염위71례(40.3％),중도만성염위80례(45.5％),중도만성염위25례(14.2％).염증세포이CD3표기양성적림파세포위주,반유소량적단핵세포급비대세포.염증정도여전렬선암급기분화정도、전렬선증생、국조성위축급기류형、고분급상피내류무상관성(균P＞0.05).COX-2적표체여염증정도상관(P＜0.05).결론 조직학적만성염증재노년인전렬선표본중상견,염증정도여전렬선암급전렬선증생무관.염증정도여COX-2표체수평정정상관,가능여양화응격유도COX-2로경활화상관.
Objective To investigate the pathological features of chronic inflammation in prostatic specimens,and study the correlation of chronic prostatic inflammation with prostate cancer and hyperplasia of prostate in the elderly.Methods The histopathologic features of prostatic specimens which were taken during prostatectomy were retrospectively observed.The inflammatory cells in partial cases were labeled by immunohistochemical markers such as CD3,CD20,CD4,CD8,CD117 and CD138,and by inflammation related factors such as nuclear factor(NF)-κB,(COX-2),tumor necrosis factor-α(TNF-α)and inducible nitric oxide synthase (iNOS).Results The chronic prostatic inflammation of different extent were found in 100 patients with prostate cancer and 76 patients with benign prostatic hyperplasia,among them 71 cases (40.3 ％) had mild chronic prostatic inflammation,80 cases (45.5 ％) had moderate chronic prostatic inflammation,25 cases (14.2 ％) had severe chronic prostatic inflammation.Inflammatory cells mainly were CD3-labeled lymphocytes,accompanied by a small amount of mononuclear cells and mast cells.Chronic prostatic inflammation was not correlated with prostatic carcinoma and its differentiation degree,benign prostatic hyperplasia,focal atrophy and its subtypes,and high grade prostatic intraepithelial neoplasia (all P＞ 0.05).There was correlation between chronic prostatic inflammation and expression of COX-2 (P＜ 0.05).Conclusions The histological chronic inflammation is common in the prostate specimens in elderly men.There are no direct correlations of prostatic inflammation with prostatic carcinomas and benign prostatic hyperplasia.Prostatic inflammation is positively correlated with the expression of COX 2,which may be associated with the activation of COX-2 pathway induced by oxidative stress.