国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2015年
5期
447-450,466
,共5页
卢爱珠%雷洪伊%徐华丽%李乐%赖露颖
盧愛珠%雷洪伊%徐華麗%李樂%賴露穎
로애주%뢰홍이%서화려%리악%뢰로영
活性氧%持续性疼痛%中枢敏化
活性氧%持續性疼痛%中樞敏化
활성양%지속성동통%중추민화
Reactive oxygen species%Persistent pain%Central sensitization
背景 中枢敏化是持续性疼痛的重要基础机制.活性氧(reactive oxygen species,ROS)为正常细胞代谢的副产品,其表达增加可诱发脊髓中枢敏化参与持续性疼痛.目的 分析总结ROS在持续性疼痛中枢敏化中作用机制的新近文献资料.内容 ROS作为中枢敏化过程的功能性信使分子参与持续性疼痛并起关键作用,目前认为其作用机制可能与谷氨酸能通路增强、神经炎症发生、γ-氨基丁酸释放减少和瞬态感受器电位阳离子通道,子类V,成员1 (transient receptor potential cation channel,subfamily V,member 1,TRPV1)活化等有关.趋向 深入研究ROS在中枢敏化中的作用机制将有助于为持续性疼痛提供坚实的治疗策略.
揹景 中樞敏化是持續性疼痛的重要基礎機製.活性氧(reactive oxygen species,ROS)為正常細胞代謝的副產品,其錶達增加可誘髮脊髓中樞敏化參與持續性疼痛.目的 分析總結ROS在持續性疼痛中樞敏化中作用機製的新近文獻資料.內容 ROS作為中樞敏化過程的功能性信使分子參與持續性疼痛併起關鍵作用,目前認為其作用機製可能與穀氨痠能通路增彊、神經炎癥髮生、γ-氨基丁痠釋放減少和瞬態感受器電位暘離子通道,子類V,成員1 (transient receptor potential cation channel,subfamily V,member 1,TRPV1)活化等有關.趨嚮 深入研究ROS在中樞敏化中的作用機製將有助于為持續性疼痛提供堅實的治療策略.
배경 중추민화시지속성동통적중요기출궤제.활성양(reactive oxygen species,ROS)위정상세포대사적부산품,기표체증가가유발척수중추민화삼여지속성동통.목적 분석총결ROS재지속성동통중추민화중작용궤제적신근문헌자료.내용 ROS작위중추민화과정적공능성신사분자삼여지속성동통병기관건작용,목전인위기작용궤제가능여곡안산능통로증강、신경염증발생、γ-안기정산석방감소화순태감수기전위양리자통도,자류V,성원1 (transient receptor potential cation channel,subfamily V,member 1,TRPV1)활화등유관.추향 심입연구ROS재중추민화중적작용궤제장유조우위지속성동통제공견실적치료책략.
Background Central sensitization is an important mechanism underlying persistent pain.Reactive oxygen species (ROS) are byproducts of normal cellular metabolism.Several studies have suggested that a excess level of ROS can cause central sensitization in the spinal cord leading to persistent pain.Objective To review the recent studies about the roles of ROS in central sensitization underlying persistent pain.Content ROS serve as functional messenger molecules in central sensitization and play a critical role in the development of persistent pain.Alterations in glutamatergic neurotransmission and neuroinflammation,reduction of spinal γ-amino butyric acid release,and modulation of ion channels such as the transient receptor potential cation channel,subfamily V,member 1 (TRPV1),have been proposed as possible mechanisms.Trend Studies concerning the roles of ROS in central sensitization will help the development of solid therapeutic strategies for persistent pain.