CAJ | 학술논문

背景瑞芬太尼是临床麻醉中应用广泛的阿片类药物,具有起效快、半衰期短、无蓄积等优点,但瑞芬太尼痛觉过敏发生率高,且目前尚无有效的预防措施.右美托咪定作为高度选择性的α2肾上腺素受体(α2-adrenergic receptor,α2AR)激动剂,具有镇静、镇痛、抗焦虑等作用.近期有文献报道,右美托咪定对瑞芬太尼痛觉过敏有预防作用.目的探讨右美托咪定对瑞芬太尼痛觉过敏的影响及机制.内容将瑞芬太尼诱发痛觉过敏可能的机制,以及右美托咪定预防瑞芬太尼痛觉过敏的证据及可能的机制进行归纳总结.趋向随着对瑞芬太尼痛觉过敏的深入研究,将为瑞芬太尼致痛觉过敏的机制研究及解决临床问题提供新的思路.
배경 서분태니시림상마취중응용엄범적아편류약물,구유기효쾌、반쇠기단、무축적등우점,단서분태니통각과민발생솔고,차목전상무유효적예방조시.우미탁미정작위고도선택성적α2신상선소수체(α2-adrenergic receptor,α2AR)격동제,구유진정、진통、항초필등작용.근기유문헌보도,우미탁미정대서분태니통각과민유예방작용.목적 탐토우미탁미정대서분태니통각과민적영향급궤제.내용 장서분태니유발통각과민가능적궤제,이급우미탁미정예방서분태니통각과민적증거급가능적궤제진행귀납총결.추향 수착대서분태니통각과민적심입연구,장위서분태니치통각과민적궤제연구급해결림상문제제공신적사로.
Background Remifentanil is widely used in clinical anesthesia with its rapid onset,short half-time,and no accumulation properties.However,the incidence of remifentanil-induced hyperalgesia remains relatively high and lack of effective preventive measures.Dexmedetomidine is a highly selective α2-adrenergic receptor(α2AR) agonist,providing sedation,analgesia and antianxiety properties.Recent studies indicated that dexmedetomidine can prevent remifentanil-induced hyperalgesia.Objective This review focus on the recent research advances in mechanisms of preventive effect of dexmedetomidine on remifentanil-induced hyperalgesia.Content This review will summarize the potential mechanisms of remifentanil-induced hyperalgesia,as well as the evidence and probable mechanisms of dexmedetomidine in preventing remifentanil-induced hyperalgesia.Trend With further in-depth studies,mechanisms of remifentanil-induced hyperalgesia will be illustrated which will further lead to new therapies.