国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2015年
5期
455-458
,共4页
酪氨酸激酶-信号转导和转录激活因子信号通路%神经病理性疼痛%星形胶质细胞
酪氨痠激酶-信號轉導和轉錄激活因子信號通路%神經病理性疼痛%星形膠質細胞
락안산격매-신호전도화전록격활인자신호통로%신경병이성동통%성형효질세포
Janus kinase-signal transducer and activator of transcription signaling pathway%Neuropathic pain%Astrocyte
背景 神经病理性疼痛(neuropathic pain,NP)是一种最常见的、最棘手的慢性疼痛之一.酪氨酸激酶-信号转导和转录激活因子(janus kinases-signal transducer and activators of transcription,JAKs-STATs)信号通路是介导细胞反应的重要信号通路系统,近年有研究表明JAKs-STATs信号通路参与NP.目的 探讨JAKs-STATs信号通路参与NP的机制.内容 分别从JAKs-STATs信号通路生物学特性、JAKs-STATs信号通路对NP调节机制的研究现状进行综述.趋向 为更好地治疗NP提供理论依据.
揹景 神經病理性疼痛(neuropathic pain,NP)是一種最常見的、最棘手的慢性疼痛之一.酪氨痠激酶-信號轉導和轉錄激活因子(janus kinases-signal transducer and activators of transcription,JAKs-STATs)信號通路是介導細胞反應的重要信號通路繫統,近年有研究錶明JAKs-STATs信號通路參與NP.目的 探討JAKs-STATs信號通路參與NP的機製.內容 分彆從JAKs-STATs信號通路生物學特性、JAKs-STATs信號通路對NP調節機製的研究現狀進行綜述.趨嚮 為更好地治療NP提供理論依據.
배경 신경병이성동통(neuropathic pain,NP)시일충최상견적、최극수적만성동통지일.락안산격매-신호전도화전록격활인자(janus kinases-signal transducer and activators of transcription,JAKs-STATs)신호통로시개도세포반응적중요신호통로계통,근년유연구표명JAKs-STATs신호통로삼여NP.목적 탐토JAKs-STATs신호통로삼여NP적궤제.내용 분별종JAKs-STATs신호통로생물학특성、JAKs-STATs신호통로대NP조절궤제적연구현상진행종술.추향 위경호지치료NP제공이론의거.
Background Neuropathic pain (NP) is one of the most common and tricky chronic pain.Janus kinases-signal transducer and activators of transcription (JAKs-STATs) signaling pathway is an important signaling pathway in mediating cell reaction system.In recent years,studies have shown that JAKs-STATs signaling pathway is closely related to NP.Objective To explore the mechanisms of JAKs-STATs signaling pathway in NP.Content This article firstly reviewed the biological characteristics of JAKs-STATs signaling pathway;then reviewed the current studies about the regulating mechanism of JAKs-STATs signaling pathway in NP.Trend It provides a new theory basis for the treatment of NP.
