中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2015年
5期
482-486
,共5页
面部单侧痉挛%磁共振成像%静息态%局部一致性
麵部單側痙攣%磁共振成像%靜息態%跼部一緻性
면부단측경련%자공진성상%정식태%국부일치성
Hemifacial spasm%Magnetic resonance imaging%Resting-state%Regional homogeneity
目的 探索面肌痉挛(HFS)患者静息态下大脑功能活动的改变.方法 对2013年7月至12月上海交通大学医学院附属瑞金医院神经外科收治的30例HFS患者(HFS组)和33例健康受试者[健康对照组(HC组)]进行血氧水平依赖功能磁共振成像(BOLD-fMRI)检查,并采用局部一致性(ReHo)方法分析两组间自发性脑功能活动的差异.结果 两组受试者的年龄、性别比例和受教育年份差异均无统计学意义,具有可比性.与HC组相比,HFS组的脑区包括脑桥、小脑后叶和中央前回运动区的ReHo值均增高(AlphaSim校正,P＜0.01),其中以中央前回运动区差异体素最多,小脑后叶次之,脑桥差异体素最小,但后者的ReHo值增高却最为显著(t=3.83);HFS组的运动辅助区、颞上回、楔前叶、额中回和扣带回的ReHo值降低(AlphaSim校正,P＜0.01),其中以扣带回的差异体素最多,ReHo值降低最为明显(t=-3.69).结论 静息态下,HFS患者大脑参与激活面肌运动的皮层和灰质核团兴奋性增高,而参与抑制面肌运动的皮层存在功能弱化,这些改变可能参与了HFS的病理进展.
目的 探索麵肌痙攣(HFS)患者靜息態下大腦功能活動的改變.方法 對2013年7月至12月上海交通大學醫學院附屬瑞金醫院神經外科收治的30例HFS患者(HFS組)和33例健康受試者[健康對照組(HC組)]進行血氧水平依賴功能磁共振成像(BOLD-fMRI)檢查,併採用跼部一緻性(ReHo)方法分析兩組間自髮性腦功能活動的差異.結果 兩組受試者的年齡、性彆比例和受教育年份差異均無統計學意義,具有可比性.與HC組相比,HFS組的腦區包括腦橋、小腦後葉和中央前迴運動區的ReHo值均增高(AlphaSim校正,P＜0.01),其中以中央前迴運動區差異體素最多,小腦後葉次之,腦橋差異體素最小,但後者的ReHo值增高卻最為顯著(t=3.83);HFS組的運動輔助區、顳上迴、楔前葉、額中迴和釦帶迴的ReHo值降低(AlphaSim校正,P＜0.01),其中以釦帶迴的差異體素最多,ReHo值降低最為明顯(t=-3.69).結論 靜息態下,HFS患者大腦參與激活麵肌運動的皮層和灰質覈糰興奮性增高,而參與抑製麵肌運動的皮層存在功能弱化,這些改變可能參與瞭HFS的病理進展.
목적 탐색면기경련(HFS)환자정식태하대뇌공능활동적개변.방법 대2013년7월지12월상해교통대학의학원부속서금의원신경외과수치적30례HFS환자(HFS조)화33례건강수시자[건강대조조(HC조)]진행혈양수평의뢰공능자공진성상(BOLD-fMRI)검사,병채용국부일치성(ReHo)방법분석량조간자발성뇌공능활동적차이.결과 량조수시자적년령、성별비례화수교육년빈차이균무통계학의의,구유가비성.여HC조상비,HFS조적뇌구포괄뇌교、소뇌후협화중앙전회운동구적ReHo치균증고(AlphaSim교정,P＜0.01),기중이중앙전회운동구차이체소최다,소뇌후협차지,뇌교차이체소최소,단후자적ReHo치증고각최위현저(t=3.83);HFS조적운동보조구、섭상회、설전협、액중회화구대회적ReHo치강저(AlphaSim교정,P＜0.01),기중이구대회적차이체소최다,ReHo치강저최위명현(t=-3.69).결론 정식태하,HFS환자대뇌삼여격활면기운동적피층화회질핵단흥강성증고,이삼여억제면기운동적피층존재공능약화,저사개변가능삼여료HFS적병리진전.
Objective To explore the changes of brain function activity under the resting state in patients with hemifacial spasm (HFS).Methods Thirty patients with HFS (HFS group) and 33 healthy controls (HC group) admitted to the Department of Neurosurgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine performed blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) examination from July 2013 to December 2013.The regional homogeneity (ReHo) method was used to analyze the differences of spontaneous brain activity between the two groups.Results There were no significant differences in age,gender and years of education between the 2 groups.They had comparability.Compared with the HC group,the brain regions of the HFS group included the increased ReHo values of pons,posterior lobe of cerebellum and precentral motor area (adjusted AlphaSim,P ＜ 0.O1).The largest difference voxel was in the precentral motor area,followed by posterior lobe of cerebellum,and the smallest difference voxel was pons,but the increased ReHo value of the latter was most significant (t =3.83);the ReHo values of the supplementary motor area,superior temporal gyrus,precuneus,middle frontal gyrus,and cingulate gyrus of the HFS group decreased (adjusted AlphaSim,P ＜ 0.01).The largest difference voxel and ReHo value was cingulate gyrus.(t =-3.69).Conclusion Under the resting state,brains involve in the activation of the cortices of facial muscle movement and the excitability of gray matter nuclei increase in patients with HFS,and the cortices involving in the inhibition of facial muscle movement have function weakening,these changes may involve in the pathological progress of HFS.
