国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2015年
5期
459-462
,共4页
麻醉,全身%睡眠%腺苷A1受体%γ-氨基丁酸A型受体%N-甲基-D-天冬氨酸受体
痳醉,全身%睡眠%腺苷A1受體%γ-氨基丁痠A型受體%N-甲基-D-天鼕氨痠受體
마취,전신%수면%선감A1수체%γ-안기정산A형수체%N-갑기-D-천동안산수체
Anesthesia,general%Sleep%Adenosine A1 receptor%γ-amino butyric acid A receptor%N-methyl-D-aspartic acid receptor
背景 由于腺苷在睡眠方面的作用与全身麻醉所产生的作用非常相似,近年来关于腺苷及其受体在全身麻醉过程作用的研究越来越多,但其机制尚无定论.目的 综述腺苷A1受体与全身麻醉的关系及在全身麻醉过程中可能的作用机制.内容 简述全身麻醉与腺苷A1受体在睡眠方面的相似之处以及全身麻醉相关的重要受体γ-氨基丁酸A型(γ-amino butyric acid A,GABAA)受体、N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid,NMDA)受体与腺苷A1受体的关系,总结目前腺苷A1受体在全身麻醉中作用的研究结果.趋向 腺苷A1受体在全身麻醉中的作用机制尚不完全清楚,有待进一步的研究证实,研究腺苷A1受体和全身麻醉之间的关系对于临床麻醉工作及药物的研究应用有一定的指导意义.
揹景 由于腺苷在睡眠方麵的作用與全身痳醉所產生的作用非常相似,近年來關于腺苷及其受體在全身痳醉過程作用的研究越來越多,但其機製尚無定論.目的 綜述腺苷A1受體與全身痳醉的關繫及在全身痳醉過程中可能的作用機製.內容 簡述全身痳醉與腺苷A1受體在睡眠方麵的相似之處以及全身痳醉相關的重要受體γ-氨基丁痠A型(γ-amino butyric acid A,GABAA)受體、N-甲基-D-天鼕氨痠(N-methyl-D-aspartic acid,NMDA)受體與腺苷A1受體的關繫,總結目前腺苷A1受體在全身痳醉中作用的研究結果.趨嚮 腺苷A1受體在全身痳醉中的作用機製尚不完全清楚,有待進一步的研究證實,研究腺苷A1受體和全身痳醉之間的關繫對于臨床痳醉工作及藥物的研究應用有一定的指導意義.
배경 유우선감재수면방면적작용여전신마취소산생적작용비상상사,근년래관우선감급기수체재전신마취과정작용적연구월래월다,단기궤제상무정론.목적 종술선감A1수체여전신마취적관계급재전신마취과정중가능적작용궤제.내용 간술전신마취여선감A1수체재수면방면적상사지처이급전신마취상관적중요수체γ-안기정산A형(γ-amino butyric acid A,GABAA)수체、N-갑기-D-천동안산(N-methyl-D-aspartic acid,NMDA)수체여선감A1수체적관계,총결목전선감A1수체재전신마취중작용적연구결과.추향 선감A1수체재전신마취중적작용궤제상불완전청초,유대진일보적연구증실,연구선감A1수체화전신마취지간적관계대우림상마취공작급약물적연구응용유일정적지도의의.
Background With more in-depth research into the role of adenosine and its receptors in general anesthesia,there were increasing evidence that the effect of adenosine on sleep and anesthesia shares similarities.However,the underlying mechanisms remain unclear.Objective To review the latest research progress of the effect and possible mechanisms of adenosine A1 receptor in general anesthesia.Content This article will highlight the similarities between the effects of adenosine in sleep and general anesthesia,as well as the correlation between adenosine A1 receptor and general anesthesia.Relevant receptors including N-methyl-D-aspartic acid(NMDA) receptor and γ-amino butyric acid A(GABAA) receptor will be discussed thoroughly.Current progress of research results of adenosine A1 receptor during general anesthesia will be summarized.Trend The effects and mechanism of adenosine A1 receptor in general anesthesia is not entirely understood and deserves further research.
