CAJ | 학술논문

背景全身麻醉药物通过增强抑制性神经传递和减弱兴奋性神经传递在中枢神经系统中发挥作用.兴奋性神经递质如谷氨酸和乙酰胆碱(acetylcholine,ACh)引起去极化,而抑制性神经递质如γ-氨基丁酸(γ-aminobutyric acid,GABA)和甘氨酸通过超极化或分流兴奋性电流来降低突触后活性.目的探讨药物分子靶点在全身麻醉中的作用机制.内容就全身麻醉药物主要分子靶点作简要介绍.趋向针对麻醉药物分子靶点对全身麻醉的促进作用所进行的研究可能有助于研发出更有效且更安全的麻醉药.
배경 전신마취약물통과증강억제성신경전체화감약흥강성신경전체재중추신경계통중발휘작용.흥강성신경체질여곡안산화을선담감(acetylcholine,ACh)인기거겁화,이억제성신경체질여γ-안기정산(γ-aminobutyric acid,GABA)화감안산통과초겁화혹분류흥강성전류래강저돌촉후활성.목적 탐토약물분자파점재전신마취중적작용궤제.내용 취전신마취약물주요분자파점작간요개소.추향 침대마취약물분자파점대전신마취적촉진작용소진행적연구가능유조우연발출경유효차경안전적마취약.
Background General anesthetics produce widespread depression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission.Excitatory neurotransmitters induce depolarization,such as glutamate and acetylcholine(ACh).Whereas inhibitory neurotransmitters reduce postsynaptic activity by hyperpolarization or shunting excitatory currents,such as γ-aminobutyric acid(GABA) and glycine.Objective To investigate the mechanisms of drug molecular targets in general anesthesia.Content In this review,we briefly introduce the research progress of drug molecular targets of general anesthesia.Trend Studies on the contributions of anesthetic targets to general anesthesia may facilitate the development of more effective and safer anesthetics.