CAJ | 학술논문

目的测定系统性红斑狼疮(SLE)患者血清中B因子水平,探讨B因子在SLE中的临床意义及其与病情活动性的关系.方法 78例SLE患者和46例健康体检者纳入本研究.用散浊比色法检测78例SLE患者及46例健康对照者血清B因子水平,按照系统性红斑狼疮疾病活动性指数(SLEDAI)评分标准,将SLE患者分为SLE活动组和SLE稳定组,分析SLE患者与健康对照组间B因子水平的差异,以及不同严重程度的SLE患者间的B因子水平差异;比较SLE活动组与SLE稳定组间B因子水平和其他实验和临床指标的差异,同时对B因子与其他实验室和临床指标的相关性进行分析.结果 SLE组血清B因子水平明显低于健康对照组[(27.13±8.98) mg/dl vs(36.73±5.47) mg/dl,t=7.4,P＜0.01],SLE组中病情活动组B因子水平明显低于病情稳定组[(21.70±7.41) mg/dl vs(35.80±8.89) mg/dl,t=7.63,P＜0.01],SLE组B因子与C3、C4呈正相关(P＜0.01),与CRP、SLEDAI评分呈负相关(P＜0.01),而与白细胞、血红蛋白、血小板、ESR等无明显相关性.结论 SLE患者BF水平降低,可能参与SLE发病机制,检测BF水平对SLE的诊断及疾病的活动性判断具有一定的意义.
목적 측정계통성홍반랑창(SLE)환자혈청중B인자수평,탐토B인자재SLE중적림상의의급기여병정활동성적관계.방법 78례SLE환자화46례건강체검자납입본연구.용산탁비색법검측78례SLE환자급46례건강대조자혈청B인자수평,안조계통성홍반랑창질병활동성지수(SLEDAI)평분표준,장SLE환자분위SLE활동조화SLE은정조,분석SLE환자여건강대조조간B인자수평적차이,이급불동엄중정도적SLE환자간적B인자수평차이;비교SLE활동조여SLE은정조간B인자수평화기타실험화림상지표적차이,동시대B인자여기타실험실화림상지표적상관성진행분석.결과 SLE조혈청B인자수평명현저우건강대조조[(27.13±8.98) mg/dl vs(36.73±5.47) mg/dl,t=7.4,P＜0.01],SLE조중병정활동조B인자수평명현저우병정은정조[(21.70±7.41) mg/dl vs(35.80±8.89) mg/dl,t=7.63,P＜0.01],SLE조B인자여C3、C4정정상관(P＜0.01),여CRP、SLEDAI평분정부상관(P＜0.01),이여백세포、혈홍단백、혈소판、ESR등무명현상관성.결론 SLE환자BF수평강저,가능삼여SLE발병궤제,검측BF수평대SLE적진단급질병적활동성판단구유일정적의의.
Objective To investigate the expression of serum B factor in the peripheral blood of patients with systemic lupus erythematosus (SLE),and explore its role in the pathogenesis.Methods Seventy eight patients with SLE in our hospital and 46 healthy persons were eligible to participate in this study.Rate nphelometyr was used to test serum B factor for 78 patients with SLE and 46 healthy controls.According to systemic lupus erythematosus disease activity index (SLEDAI),participants were divided into steady SLE group (SLEDAI ＜ 5) and active SLE group (SLEDAI ≥5),which was further divided into mild,moderate,and serious subgroups.The differences in serum B factor between SLE patients and healthy controls,including SLE patients with different severity,were all compared.Then we analyzed the differences in serum B factor and other laboratory and clinical indexes between active and steady SLE patients.The correction of serum B factor and other laboratory and clinical indexes were also analyzed.Results Compared to healthy controls,patients with SLE had significantly lower value of serum B factor [(27.13 ± 8.98) mg/dl vs (36.73 ± 5.47) mg/dl,t =7.4,P ＜ 0.01].Compared to steady SLE group,SLE active group had significantly lower level of serum factor B,C3 and C4,and also had significant higher level of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (all P ＜ 0.05).Moreover,There were significant differences in the lower level of serum B factor between subgroups.Correlation analysis showed that the level of serum B factor was negatively associated with the levels of CRP and SLEDAI scores,whereas serum B factor was positively associated with the levels of C3 and C4 (all P ＜ 0.05).Conclusions Serum B factor is related to SLE.Serum B factor might be involved in the pathogenesis of SLE.Detection of serum B factor is helpful for diagnosis and evaluation of SLE disease activity.