CAJ | 학술논문

目的探讨性别对金属对金属全髋表面置换术(RHA)后血清钴、铬、钼离子水平的影响. 方法收集2008年11月至2013年3月因交通伤导致的24例单侧股骨头骨折患者,根据性别不同分为两组:男性组12例,平均年龄为(54.7±5.9)岁,股骨头骨折分型:31-C1型5例,31-C2型7例;女性组12例,平均年龄为(53.9±5.8)岁,股骨头骨折分型:31-C1型6例,31-C2型6例.所有患者均行金属对金属RHA治疗.分别于术前、术后3个月、6个月、9个月及12个月应用电化学微量元素测定法测量患者血清中钴、铬、钼离子的浓度,并比较两组患者的差异. 结果男性组和女性组患者术后血清钴、铬离子浓度明显升高,术后6个月达到高峰,此后开始下降.男性组患者术后3、6、9及12个月时血清钴离子浓度平均分别为(1.37±0.50)、(2.51 ±0.78)、(1.99±0.46)、(1.26±0.60)μg/L,铬离子浓度平均分别为(0.98 ±0.18)、(1.39±0.44)、(1.12±0.21)、(0.74±0.15) μg/L.女性组患者术后血清钴离子浓度平均分别为(1.23±0.59)、(2.17 ±0.82)、(1.79 ±0.43)、(1.23±0.11)μg/L,铬离子浓度平均分别为(0.90 ±0.20)、(1.19±0.31)、(1.03±0.20)、(0.74±0.17)μg/L.两组患者术后3、6、9及12个月血清钼离子浓度无明显变化.除了术后9个月男性组患者铬离子浓度显著高于女性组患者(P＜0.05)外,其他时间点两组患者钴、铬、钼离子浓度比较差异均无统计学意义(P＞0.05). 结论除术后9个月男性患者铬离子浓度显著高于女性患者外,其他时间点男性与女性患者钴、铬、钼离子浓度差异不明显.
목적 탐토성별대금속대금속전관표면치환술(RHA)후혈청고、락、목리자수평적영향. 방법 수집2008년11월지2013년3월인교통상도치적24례단측고골두골절환자,근거성별불동분위량조:남성조12례,평균년령위(54.7±5.9)세,고골두골절분형:31-C1형5례,31-C2형7례;녀성조12례,평균년령위(53.9±5.8)세,고골두골절분형:31-C1형6례,31-C2형6례.소유환자균행금속대금속RHA치료.분별우술전、술후3개월、6개월、9개월급12개월응용전화학미량원소측정법측량환자혈청중고、락、목리자적농도,병비교량조환자적차이. 결과 남성조화녀성조환자술후혈청고、락리자농도명현승고,술후6개월체도고봉,차후개시하강.남성조환자술후3、6、9급12개월시혈청고리자농도평균분별위(1.37±0.50)、(2.51 ±0.78)、(1.99±0.46)、(1.26±0.60)μg/L,락리자농도평균분별위(0.98 ±0.18)、(1.39±0.44)、(1.12±0.21)、(0.74±0.15) μg/L.녀성조환자술후혈청고리자농도평균분별위(1.23±0.59)、(2.17 ±0.82)、(1.79 ±0.43)、(1.23±0.11)μg/L,락리자농도평균분별위(0.90 ±0.20)、(1.19±0.31)、(1.03±0.20)、(0.74±0.17)μg/L.량조환자술후3、6、9급12개월혈청목리자농도무명현변화.제료술후9개월남성조환자락리자농도현저고우녀성조환자(P＜0.05)외,기타시간점량조환자고、락、목리자농도비교차이균무통계학의의(P＞0.05). 결론 제술후9개월남성환자락리자농도현저고우녀성환자외,기타시간점남성여녀성환자고、락、목리자농도차이불명현.
Objective To study the effect of gender on the serum ion levels of Co,Cr and Mo in the patients who have undergone metal-on-metal resurfacing hip arthroplasty.Methods Enrolled in the present study were 24 patients with fracture of uni-lateral femoral head who were injured from November 2008 to March 2013 in traffic accidents.There were 12 men,with an average age of 54.7 ± 5.9 years,including 5 cases of type 31-C1 and 7 cases of 31-C2.There were also 12 women,with an average age of 53.9 ±5.8 years,including 6 cases of type 31-C1 and 6 cases of 31-C2.All the patients received metal-on-metal resurfacing hip arthroplasty.The ion levels of Co,Cr and Mo in the serum of the patients were measured by electrochemical trace element determination at 3,6,9 and 12 months after surgery for comparison between the male and female groups.Results The ion concentrations of Co and Cr in both groups significantly increased and then decreased after reaching the peak at 6 months post-surgery.In the male group at 3,6,9 and 12 months after surgery,the Co levels were respectively 1.37 ±0.50 μg/L,2.51 ±0.78 μg/L,1.99 ± 0.46 μg/L and 1.26 ±0.60 μg/L and the Cr levels were respectively 0.98 ±0.18 μg/L,1.39 ±0.44 μg/L,1.12±0.21 μg/L and 0.74±0.15 μg/L.In the female group at 3,6,9 and 12 months after surgery,the Co levels were respectively 1.23 ±0.59 μg/L,2.17 ±0.82 μg/L,1.79 ±0.43 μg/L and 1.23 ±0.11 μg/L and the Cr levels were respectively 0.90 ±0.20 μg/L,1.19 ±0.31 μg/L,1.03 ±0.20 μg/L and 0.74 ± 0.17 μg/L.There was no significant change in the ion concentration of Mo in either male or female groups after surgery.No significant differences were found in the ion levels of Co,Cr or Mo after surgery between the 2 groups (P ＞ 0.05) except that the Cr ion level in the male patients was significantly higher than that in the female patients at 9 months after surgery (P ＜ 0.05).Conclusion No significant differences can be found in the ion levels of Co,Cr or Mo after surgery between males and females except that the Cr ion level in the male patients may be significantly higher than that in the female patients at 9 months after surgery.