风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2015年
5期
18-21
,共4页
张晓东%刘立云%邢庆胜%杜贵强
張曉東%劉立雲%邢慶勝%杜貴彊
장효동%류립운%형경성%두귀강
下肢深静脉血栓%全髋关节置换术%低分子肝素钙%补中益气汤%剂量%应用研究
下肢深靜脈血栓%全髖關節置換術%低分子肝素鈣%補中益氣湯%劑量%應用研究
하지심정맥혈전%전관관절치환술%저분자간소개%보중익기탕%제량%응용연구
deep vein thrombosis%total hip replacement%low molecular heparin calcium%Buzhong Yiqi Tang (补中益气汤)%dose%research on application
目的：观察补中益气汤联合不同剂量分子肝素钙对预防全髋关节置换术后下肢深静脉血栓的疗效。方法：将231例行单侧人工髋关节置换术患者随机分为补中益气汤组（A组）62例，补中益气汤+低分子肝素钙标准剂量组（B组）60例，补中益气汤+低分子肝素钙1/2剂量组（C组）53例，补中益气汤+低分子肝素钙1/4剂量组（D组）56例。A组患者于术后给予单纯补中益气汤，其余3组患者术后给予补中益气汤联合对应剂量低分子肝素钙，比较4组患者术后下肢深静脉血栓及不良反应的发生率，并于术后第14天检测患者血小板计数及凝血五项。结果：A组术后下肢深静脉血栓9例，发生率为14.52%；B组术后下肢深静脉血栓3例，发生率为5.00%；C组术后下肢深静脉血栓5例，发生率为9.43%；D组术后下肢深静脉血栓7例，发生率为12.50%。B组与各组比较，差异有统计学意义（P <0.05）。4组患者血小板计数及凝血五项比较，差异均无统计学意义（P >0.05）。结论：补中益气汤配合低分子肝素钙标准剂量预防髋关节术后深静脉血栓形成疗效确切，对凝血机制无影响，安全性好。
目的：觀察補中益氣湯聯閤不同劑量分子肝素鈣對預防全髖關節置換術後下肢深靜脈血栓的療效。方法：將231例行單側人工髖關節置換術患者隨機分為補中益氣湯組（A組）62例，補中益氣湯+低分子肝素鈣標準劑量組（B組）60例，補中益氣湯+低分子肝素鈣1/2劑量組（C組）53例，補中益氣湯+低分子肝素鈣1/4劑量組（D組）56例。A組患者于術後給予單純補中益氣湯，其餘3組患者術後給予補中益氣湯聯閤對應劑量低分子肝素鈣，比較4組患者術後下肢深靜脈血栓及不良反應的髮生率，併于術後第14天檢測患者血小闆計數及凝血五項。結果：A組術後下肢深靜脈血栓9例，髮生率為14.52%；B組術後下肢深靜脈血栓3例，髮生率為5.00%；C組術後下肢深靜脈血栓5例，髮生率為9.43%；D組術後下肢深靜脈血栓7例，髮生率為12.50%。B組與各組比較，差異有統計學意義（P <0.05）。4組患者血小闆計數及凝血五項比較，差異均無統計學意義（P >0.05）。結論：補中益氣湯配閤低分子肝素鈣標準劑量預防髖關節術後深靜脈血栓形成療效確切，對凝血機製無影響，安全性好。
목적：관찰보중익기탕연합불동제량분자간소개대예방전관관절치환술후하지심정맥혈전적료효。방법：장231례행단측인공관관절치환술환자수궤분위보중익기탕조（A조）62례，보중익기탕+저분자간소개표준제량조（B조）60례，보중익기탕+저분자간소개1/2제량조（C조）53례，보중익기탕+저분자간소개1/4제량조（D조）56례。A조환자우술후급여단순보중익기탕，기여3조환자술후급여보중익기탕연합대응제량저분자간소개，비교4조환자술후하지심정맥혈전급불량반응적발생솔，병우술후제14천검측환자혈소판계수급응혈오항。결과：A조술후하지심정맥혈전9례，발생솔위14.52%；B조술후하지심정맥혈전3례，발생솔위5.00%；C조술후하지심정맥혈전5례，발생솔위9.43%；D조술후하지심정맥혈전7례，발생솔위12.50%。B조여각조비교，차이유통계학의의（P <0.05）。4조환자혈소판계수급응혈오항비교，차이균무통계학의의（P >0.05）。결론：보중익기탕배합저분자간소개표준제량예방관관절술후심정맥혈전형성료효학절，대응혈궤제무영향，안전성호。
[ABSTRACT]Objective:To observe the curative effect ofBuzhong Yiqi Tang(补中℃气汤) combined with different doses of heparin calcium to prevent the form of lower extremity deep venous thrombosis after total hip arthroplasty.Methods:231 cases of patients with unilateral hip arthroplasty were randomly divided into aBuzhong Yiqi Tanggroup(group A,62 cases),aBuzhong Yiqi Tang+ low molecular weight heparin calcium standard dose group(group B,60 cases),aBuzhong Yiqi Tang + 1/2 low molecular weight heparin dose group(group C,53 cases),and aBuzhong Yiqi Tang + 1/4 low molecular weight heparin dose group(group D,56 cases).After operation,group A was treated withBuzhong Yiqi Tang,while the other 3 groups were treated withBuzhong Yiqi Tang combined with corresponding dose of low molecular heparin calcium,comparing the deep vein thrombosis of the lower extremity and the incidence of adverse reactions in the 4 groups and detecting the blood platelet count and the ifve items of thromboxane.Results:In group A,9 cases had postoperative lower extremity deep venous thrombosis,the incidence rate being 14.52%;in group B,3 cases had postoperative deep vein thrombosis,the incidence rate being 5%;in group C,5 cases had deep venous thrombosis of lower extremity after operation,the incidence rate being 9.43%;and in group D,postoperative deep vein thrombosis appeared in 7 cases,the incidence rate being 12.50%.The difference between group B and other groups was statistically significant(P < 0.05).The difference of the blood platelet count and the ifve items of thromboxane of the 4 groups was not statistically signiifcant (P > 0.05).Conclusion: Buzhong Yiqi Tang combined with low molecular weight heparin calcium has a curative effect in the prevention of postoperative hip deep vein thrombosis,safe,and with no effect on the blood coagulation mechanism.
