CAJ | 학술논문

目的分析婴幼儿(＜3岁)反复喘息(发作次数≥3次)的相关危险因素.方法以“喘息、危险因素、影响因素”为中文关键词,“wheezing、stridor、respiratory sounds、risk factor”为英文关键词,检索中国生物医学文献服务系统、万方数据库、中文科技期刊数据库等中文数据库,PubMed、Cochrane library、EMbase等英文数据库中2004年5月31日至2014年6月1日的有关文献.使用纽卡斯尔-渥太华量表及美国卫生保健质量和研究机构推荐横断面研究评价标准对纳入的文献进行质量评价,使用GRADEpro软件评价证据质量,用RevMan 5.2软件进行Meta分析.结果最终纳入13篇文献.其中母孕时吸烟(OR=1.47,95％ CI:1.30～ 1.66),父母有支气管哮喘(哮喘)史(OR=1.94,95％ CI:1.72～2.19),家族过敏倾向(OR=1.39,95％ CI:1.03～1.88),男童(OR=1.42,95％ CI:1.19～1.69),湿疹史(OR =2.36,95％ CI:1.69～3.30),多次感冒史(＞6次)(OR=2.02,95％ CI:1.54～2.64),肺炎史(OR=1.85,95％CI:1.46～ 2.34),香烟暴露史(OR=2.30,95％ CI:1.68～3.14),幼托(OR=2.27,95％ CI:1.97 ～ 2.60)是婴幼儿(＜3岁)反复喘息(发作次数≥3次)的危险因素;母亲受教育＞12年(OR =0.80,95％ CI:0.70～0.92)为保护因素.结论婴幼儿(＜3岁)反复喘息(发作次数≥3次)的危险因素有母孕时吸烟、父母有哮喘史、家族过敏倾向、男童、湿疹史、多次感冒史、肺炎史、香烟暴露史和幼托,保护因素为母亲受教育＞12年.尽可能地规避危险因素,加强保护因素,对于预防婴幼儿反复喘息具有重要作用.
목적 분석영유인(＜3세)반복천식(발작차수≥3차)적상관위험인소.방법 이“천식、위험인소、영향인소”위중문관건사,“wheezing、stridor、respiratory sounds、risk factor”위영문관건사,검색중국생물의학문헌복무계통、만방수거고、중문과기기간수거고등중문수거고,PubMed、Cochrane library、EMbase등영문수거고중2004년5월31일지2014년6월1일적유관문헌.사용뉴잡사이-악태화량표급미국위생보건질량화연구궤구추천횡단면연구평개표준대납입적문헌진행질량평개,사용GRADEpro연건평개증거질량,용RevMan 5.2연건진행Meta분석.결과 최종납입13편문헌.기중모잉시흡연(OR=1.47,95％ CI:1.30～ 1.66),부모유지기관효천(효천)사(OR=1.94,95％ CI:1.72～2.19),가족과민경향(OR=1.39,95％ CI:1.03～1.88),남동(OR=1.42,95％ CI:1.19～1.69),습진사(OR =2.36,95％ CI:1.69～3.30),다차감모사(＞6차)(OR=2.02,95％ CI:1.54～2.64),폐염사(OR=1.85,95％CI:1.46～ 2.34),향연폭로사(OR=2.30,95％ CI:1.68～3.14),유탁(OR=2.27,95％ CI:1.97 ～ 2.60)시영유인(＜3세)반복천식(발작차수≥3차)적위험인소;모친수교육＞12년(OR =0.80,95％ CI:0.70～0.92)위보호인소.결론 영유인(＜3세)반복천식(발작차수≥3차)적위험인소유모잉시흡연、부모유효천사、가족과민경향、남동、습진사、다차감모사、폐염사、향연폭로사화유탁,보호인소위모친수교육＞12년.진가능지규피위험인소,가강보호인소,대우예방영유인반복천식구유중요작용.
Obgective To analyze the relevant risk factors of recurrent wheezing(≥3 attacks) in the first 3 years of life.Methods "Wheezing,respiratory sounds,risk factor" were used as key words to retrieve papers in Chinese literature databases including Sinomed,Wanfang and Weipu databases.The same strategy was used to retrieve English papers in English literature databases including PubMed,Cochrane library and Embase.Time range was from 31th May 2004 to 1 rd June 2014.The execution of quality evaluation of the included documents was in compliance with Newcastle-Ottawa Scale and cross-sectional study standard recommended by Agency for Healthcare Research and Quality.The evidence quality evaluation was conducted with GRADEpro and followed by the Meta analysis with RevMan 5.2.R~ults A total of 13 studies were included in this Meta-analysis.Several factors were related to recurrent wheezing episodes,including risk factors such as maternal smoking during pregnancy (OR =1.47,95％ CI:1.30-1.66),asthma in parents (OR =1.94,95 ％ CI:1.72-2.19),family history of atopy (OR =1.94,95％ CI:1.72-2.19),male (OR =1.42,95 ％ CI:1.19-1.69),history of eczema (OR =2.36,95 ％ CI:1.69-3.30),colds (＞ 6 times) (OR =2.02,95 ％ CI:1.54-2.64),history of bronchopneumonia (OR =1.85,95 ％ CI:1.46-2.34),exposure to cigarette smoking(OR =2.30,95％ CI:1.68-3.14),daycare attendance(OR =2.27,95％ CI:1.97-2.60);Education received by the mother ＞ 12 years (OR =0.80,95％ CI:0.70-0.92) was the protective factor.Conclusions The risk factors of recurrent wheezing(≥3 attacks) in the first 3 years of life are maternal smoking during pregnancy,asthma in parents,family history of atopy,male,history of eczema,colds (＞ 6 times),history of bronchopneumonia,exposure to cigarette smoking and daycare attendance.The protective factor is education received by the mother ≥ 12 years.The prerequisite in precaution of infants recurrent wheezing is to ensure the utmost avoidance of hazardous factors and reinforcement of protective factors.