CAJ | 학술논문

目的：对中药内服联合玻璃酸钠注射治疗膝骨关节炎的疗效进行循证医学评价。方法：计算机网络检索中国生物医学文献数据库、维普网、中国知网和万方数据库，筛选中药内服配合玻璃酸钠关节注射的临床随机对照试验，并用Meta分析法将数据进行统计学合并，对其疗效进行评判。结果：治疗约5周后，Meta分析结果显示：OR =4.01，95%CI =[3.04，5.29]，P <0.00001；RR =1.44，95%CI =[1.26，1.65]，P <0.00001。治疗后约25周时，OR =3.40，95%CI =[0.98，11.80]，P=0.05。结论：中药内服联合玻璃酸钠注射治疗膝骨关节炎的近期疗效明显优于单纯玻璃酸钠治疗，平均疗效约高44%；但这个治疗优势在随访至25周时已不明显。
목적：대중약내복연합파리산납주사치료슬골관절염적료효진행순증의학평개。방법：계산궤망락검색중국생물의학문헌수거고、유보망、중국지망화만방수거고，사선중약내복배합파리산납관절주사적림상수궤대조시험，병용Meta분석법장수거진행통계학합병，대기료효진행평판。결과：치료약5주후，Meta분석결과현시：OR =4.01，95%CI =[3.04，5.29]，P <0.00001；RR =1.44，95%CI =[1.26，1.65]，P <0.00001。치료후약25주시，OR =3.40，95%CI =[0.98，11.80]，P=0.05。결론：중약내복연합파리산납주사치료슬골관절염적근기료효명현우우단순파리산납치료，평균료효약고44%；단저개치료우세재수방지25주시이불명현。
Objective:To make a systemic evaluation of treating knee osteoarthritis with oral medicinal herbs combining sodium hyaluronate injection.Methods:Retrieved CBM,VIP,CNKI and Wan Fang database to screen clinical randomized controlled trials with oral medicinal herbs combined with injection of sodium hyaluronate,using Meta analysis method to make a statistical combination of data,and making an evaluation of the effects.Results:After about 5-week treatment,the Results of Meta analysis for the effects showed as follows:OR= 4.01,95% CI =(3.04,5.29),P < 0.000 01;RR = 1.44,95% CI =(1.26,1.65),P < 0.000 01.About 25 weeks after the treatment,OR= 3.40,95% CI =(0.98,11.80),P = 0.05.Conclusion:The effect of oral medicinal herbs combined with sodium hyaluronate injection is better than that of the sodium hyaluronate in the treatment of knee osteoarthritis.The average effect was higher by 44%,but not obvious 25 weeks after the follow-up.