国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2015年
5期
479-480,后插1
,共3页
蛋白激酶B通路%肿瘤复发%阿片类受体
蛋白激酶B通路%腫瘤複髮%阿片類受體
단백격매B통로%종류복발%아편류수체
Protein kinase B pathway%Tumor recurrence%Opioid receptors
背景 肿瘤复发是目前肿瘤患者治疗中要面对的一个难题,而蛋白激酶B(protein kinase B,Akt,又称PKB)通路在调控细胞增生和凋亡中具有重要作用;阿片类受体在细胞上的表达程度和活化与各类癌细胞的生物学效应密切相关.目的 探讨阿片类受体在Akt通路相关肿瘤复发中的作用.内容 Akt的高表达和肿瘤复发有着密切关联,而阿片类受体则和Akt通路有着复杂的关系.趋向 阿片类药物在临床上广泛应用,深入研究其对肿瘤的作用机制将为癌症患者安全麻醉和止痛提供参考.
揹景 腫瘤複髮是目前腫瘤患者治療中要麵對的一箇難題,而蛋白激酶B(protein kinase B,Akt,又稱PKB)通路在調控細胞增生和凋亡中具有重要作用;阿片類受體在細胞上的錶達程度和活化與各類癌細胞的生物學效應密切相關.目的 探討阿片類受體在Akt通路相關腫瘤複髮中的作用.內容 Akt的高錶達和腫瘤複髮有著密切關聯,而阿片類受體則和Akt通路有著複雜的關繫.趨嚮 阿片類藥物在臨床上廣汎應用,深入研究其對腫瘤的作用機製將為癌癥患者安全痳醉和止痛提供參攷.
배경 종류복발시목전종류환자치료중요면대적일개난제,이단백격매B(protein kinase B,Akt,우칭PKB)통로재조공세포증생화조망중구유중요작용;아편류수체재세포상적표체정도화활화여각유암세포적생물학효응밀절상관.목적 탐토아편류수체재Akt통로상관종류복발중적작용.내용 Akt적고표체화종류복발유착밀절관련,이아편류수체칙화Akt통로유착복잡적관계.추향 아편류약물재림상상엄범응용,심입연구기대종류적작용궤제장위암증환자안전마취화지통제공삼고.
Background Tumor recurrence represents a major clinical challenge for clinicans.It is known that the protein kinase B (Akt) pathway plays an indispensable role in cell proliferation and apoptosis.The expression level and activation of opioid receptors are closely related to the biological effects of various cancer cells.Objective This article will explore the role of opioid receptors-mediated Akt signaling pathway in tumor recurrence.Content There is a close relation between the high expression of Akt and tumor recurrence.Regulation mechanisms of opioid receptors with Akt pathways are explored.Trend Opioids analgesics are widely used in clinical practice.Further research are warranted to investigate the mechanisms of tumor recurrence,which will further provides evidence for clinical anesthesia and analgesia safety in cancer patients.
