CAJ | 학술논문

目的：评价万古霉素治疗医院获得性耐甲氧西林金黄色葡萄球菌（M RS A ）肺炎的疗效及安全性。方法回顾性分析2011年1月—2014年4月应用万古霉素治疗的80例医院获得性MRSA肺炎患者临床资料，观察治疗前后患者临床症状、体征、实验室检查、细菌学检查及影像学检查变化，同时观察治疗中出现的不良反应。结果80例MRSA肺炎患者治愈41例，显效19例，进步15例，无效5例，治疗总有效率75．0％（60／80）；治疗后白细胞计数、降钙素原值明显下降，差异有统计学意义（ P＜0．01）；MRSA清除率为82．5％；不良反应发生率为8．8％。结论万古霉素是治疗医院获得性MRSA肺炎有效、安全的药物。
목적：평개만고매소치료의원획득성내갑양서림금황색포도구균（M RS A ）폐염적료효급안전성。방법회고성분석2011년1월—2014년4월응용만고매소치료적80례의원획득성MRSA폐염환자림상자료，관찰치료전후환자림상증상、체정、실험실검사、세균학검사급영상학검사변화，동시관찰치료중출현적불량반응。결과80례MRSA폐염환자치유41례，현효19례，진보15례，무효5례，치료총유효솔75．0％（60／80）；치료후백세포계수、강개소원치명현하강，차이유통계학의의（ P＜0．01）；MRSA청제솔위82．5％；불량반응발생솔위8．8％。결론만고매소시치료의원획득성MRSA폐염유효、안전적약물。
Objective To evaluate the efficacy and safety of vancomycin in the treatment of hospital‐acquired methicillin‐resistant Staphylococcus aureus (HA‐MRSA) pneumonia .Methods A retrospective analysis was conducted with the clinical data of 80 patients with HA‐MRSA pneumonia treated with vancomycin during the period from January 2011 to April 2014 . The data for analysis included clinical symptoms and signs ,laboratory test results ,microbiology tests ,X‐ray findings ,and drug adverse reactions .Results The overall efficacy rate was 75 .0% (60/80) .Of the 80 cases ,41 were cured ,19 significantly improved ,15 improved ,and 5 failed .White blood cell count and serum procalcitonin decreased significantly after treatment with vancomycin (P< 0 .01) .Overall ,82 .5% of the MRSA strains were eradicated .The overall incidence of drug‐related adverse reactions was 8 .8% .Conclusions Vancomycin is an effective and safe drug for HA‐MRSA pneumonia .