CAJ | 학술논문

糖尿病神经痛（diabetic neuropathic pain，DNP）作为临床上最常见的并发症之一，极大地影响了患者的生活质量，目前发病机制尚不明确，缺少有效的治疗方法。 DNP 与周围感觉神经兴奋性增强有关，涉及多种离子通道、受体表达、功能上调，已有研究表明 P2X3受体参与 DNP 等多种神经病理痛的痛觉形成、传导和调节，本文将围绕 DNP 模型的建立及 P2X3受体在 DNP 模型中的作用予以综述。
당뇨병신경통（diabetic neuropathic pain，DNP）작위림상상최상견적병발증지일，겁대지영향료환자적생활질량，목전발병궤제상불명학，결소유효적치료방법。 DNP 여주위감각신경흥강성증강유관，섭급다충리자통도、수체표체、공능상조，이유연구표명 P2X3수체삼여 DNP 등다충신경병리통적통각형성、전도화조절，본문장위요 DNP 모형적건립급 P2X3수체재 DNP 모형중적작용여이종술。
Diabetic neuropathic pain(DNP)is one of the most common complications in clinical, which influenced patients’ daily functions greatly, without clear mechanisms and effective methods.P2X3 receptors play a pivotal role in the formation, transmission and conduction of pain under neuropathic pain models, associated with peripheral sensory nerve excitability enhancement.This paper focuses on the establishment of DNP models, and the effects of P2X3 receptors in diabetes mellitus.