CAJ | 학술논문

目的：探讨超声射频信号定量技术评价血脂异常患者颈总动脉内-中膜厚度（IMT）和弹性改变及高密度脂蛋白胆固醇（HDL-C）对颈总动脉结构和弹性功能的影响。资料与方法选取血脂异常患者150例作为高脂血症组，分为高血脂伴HDL-C升高50例（A组）、高血脂而HDL-C正常50例（B组）、高血脂伴HDL-C降低50例（C组），同期选取体检健康者50例作为对照组（D组）。应用超声射频信号技术分析高脂血症及HLD-C对颈总动脉IMT及弹性参数顺应性系数（CC）、僵硬度指数（β）、脉搏波传导速度（PWV）、动脉反射波增强指数（AIx）的影响。结果 B组IMT、β、PWV、AIx较D组增高，CC降低，差异有统计学意义（t=5.141、4.219、4.898、4.142、－3.758，P<0.05）。B组的IMT、β、PWV、AIx较A组升高，CC较A组降低，差异均有统计学意义（t=3.425、2.807、2.913、2.209、－2.091，P<0.05、P<0.01）；C组的IMT、β、PWV、AIx较B组升高，CC较B组降低，差异均有统计学意义（t=4.937、2.195、3.337、2.067、－3.049，P<0.05、P<0.01））；A组IMT、PWV较D组升高，差异均有统计学意义（t=2.236、2.407，P<0.05），而CC、β、AIx与D组比较差异无统计学意义（t=－1.693、1.845、1.967，P>0.05）。HDL-C升高可降低高血脂患者颈动脉IMT和僵硬度，升高弹性，反之颈动脉IMT和僵硬度增加，弹性下降。结论超声射频信号技术能够自动、实时、准确测量血脂异常患者颈总动脉IMT和动脉弹性，可为临床评价动脉早期结构和功能变化及调脂治疗提供较为准确的定量指标。
목적：탐토초성사빈신호정량기술평개혈지이상환자경총동맥내-중막후도（IMT）화탄성개변급고밀도지단백담고순（HDL-C）대경총동맥결구화탄성공능적영향。자료여방법선취혈지이상환자150례작위고지혈증조，분위고혈지반HDL-C승고50례（A조）、고혈지이HDL-C정상50례（B조）、고혈지반HDL-C강저50례（C조），동기선취체검건강자50례작위대조조（D조）。응용초성사빈신호기술분석고지혈증급HLD-C대경총동맥IMT급탄성삼수순응성계수（CC）、강경도지수（β）、맥박파전도속도（PWV）、동맥반사파증강지수（AIx）적영향。결과 B조IMT、β、PWV、AIx교D조증고，CC강저，차이유통계학의의（t=5.141、4.219、4.898、4.142、－3.758，P<0.05）。B조적IMT、β、PWV、AIx교A조승고，CC교A조강저，차이균유통계학의의（t=3.425、2.807、2.913、2.209、－2.091，P<0.05、P<0.01）；C조적IMT、β、PWV、AIx교B조승고，CC교B조강저，차이균유통계학의의（t=4.937、2.195、3.337、2.067、－3.049，P<0.05、P<0.01））；A조IMT、PWV교D조승고，차이균유통계학의의（t=2.236、2.407，P<0.05），이CC、β、AIx여D조비교차이무통계학의의（t=－1.693、1.845、1.967，P>0.05）。HDL-C승고가강저고혈지환자경동맥IMT화강경도，승고탄성，반지경동맥IMT화강경도증가，탄성하강。결론초성사빈신호기술능구자동、실시、준학측량혈지이상환자경총동맥IMT화동맥탄성，가위림상평개동맥조기결구화공능변화급조지치료제공교위준학적정량지표。
PurposeTo explore the value of ultrasound radio frequency technique in the quantitative evaluation of common carotid artery intima-media thickness (IMT) and elasticity change in patients with dyslipidemia, and to discuss the influence of high density lipoprotein cholesterol (HDL-C) upon carotid artery structure and elasticity function. Materials and Methods A hundred and fifty patients with abnormal serum lipid were selected as case group and further divided into three groups: group A--50 patients with hyperlipidemia and high HDL-C, group B--50 patients with hyperlipidemia and normal HDL-C, group C--50 patients with hyperlipidemia and low HDL-C. Meanwhile, 50 healthy people were enrolled in the study as control group (group D). The ultrasound radio frequency-data technique was employed to analyze the influence of hyperlipidemia and HDL-C upon IMT, CC,β, PWV and AIx.Results The IMT,β, PWV and AIx in group B were higher than those in group D, but group B had lower CC (the differences with statistic significance,t=5.141, 4.219, 4.898, 4.142 and-3.758,P<0.01). Compared with group A, group B had higher IMT,β, PWV and AIx and lower CC (the differences with statistic significance,t=3.425, 2.807, 2.913, 2.209 and-2.091,P<0.05 orP<0.01). Compared with group B, group C had higher IMT,β, PWV and AIx and lower CC (the differences with statistic significance,t=4.937, 2.195, 3.337, 2.067 and-3.049, P<0.05 orP<0.01). Group A had higher IMT and PWV than group D (the differences with statistic significance,t=2.236 and 2.407,P<0.05), but CC,β, and AIx showed no difference between group A and group D (t=-1.693, 1.845 and 1.967,P>0.05). In patients with hyperlipidemia, the increase of HDL-C led to the reduction of the common carotid artery IMT and wall stiffness and the increase of elasticity and vice versa.Conclusion The ultrasound radio frequency technique could measure the real-time common carotid artery IMT and elasticity automatically and accurately, thus provides reliable quantitative index for the evaluation of early artery structure and change of function in lipid lowering therapy.