中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
6期
755-758,759
,共5页
疼痛%神经系统%鞘氨醇-1-磷酸受体亚型1%G蛋白偶联受体%鞘氨醇-1-磷酸%FTY720%激动剂
疼痛%神經繫統%鞘氨醇-1-燐痠受體亞型1%G蛋白偶聯受體%鞘氨醇-1-燐痠%FTY720%激動劑
동통%신경계통%초안순-1-린산수체아형1%G단백우련수체%초안순-1-린산%FTY720%격동제
pain%nervous system%sphingosine-1-phosphate re-ceptor 1%G protein-coupled receptor%sphingosine-1-phosphate%FTY720%agonist
鞘氨醇-1-磷酸受体1( sphingosine-1-phosphate receptor 1,S1PR1)属于G蛋白偶联受体,其能调节多种下游信号分子和细胞功能。研究发现S1PR1在疼痛中发挥重要作用,但激活S1PR1产生致痛作用还是镇痛作用尚存在争议。该文讨论了 S1P/S1PR1信号在疼痛研究中的最新观点与进展,以增进对其生物学功能及病理作用的了解。
鞘氨醇-1-燐痠受體1( sphingosine-1-phosphate receptor 1,S1PR1)屬于G蛋白偶聯受體,其能調節多種下遊信號分子和細胞功能。研究髮現S1PR1在疼痛中髮揮重要作用,但激活S1PR1產生緻痛作用還是鎮痛作用尚存在爭議。該文討論瞭 S1P/S1PR1信號在疼痛研究中的最新觀點與進展,以增進對其生物學功能及病理作用的瞭解。
초안순-1-린산수체1( sphingosine-1-phosphate receptor 1,S1PR1)속우G단백우련수체,기능조절다충하유신호분자화세포공능。연구발현S1PR1재동통중발휘중요작용,단격활S1PR1산생치통작용환시진통작용상존재쟁의。해문토론료 S1P/S1PR1신호재동통연구중적최신관점여진전,이증진대기생물학공능급병리작용적료해。
Sphingosine-1-phosphate receptor 1(S1PR1) is a new member of G protein-coupled receptor family. A great body of data suggest S1PR1 is capable of regulating lots of downstream signaling molecules and cellular processes. It is found that S1P/S1PR1 plays an important role in the development and mainte-nance of pain. However, it is controversial whether activation of S1PR1 would enhance or attenuate pain. Here, recent studies <br> and current perspectives are discussed in order to better under-stand the biological and pathological roles of S1PR1 in pain mod-ulation.
