CAJ | 학술논문

目的：研究毛蚶提取物和 NP 方案化疗药物合用后有无增效和减毒作用。方法采用人肺癌 A549细胞株制备裸鼠移植瘤模型，通过检测抑瘤率、体重、摄食量、血液学和血液生化学等指标，全面评价毛蚶提取物和NP 化疗方案合用后的增效减毒作用。结果毛蚶提取物（125、250、500 mg／kg， i．g）与 NP 化疗方案合用比单用NP 化疗方案抑瘤率明显提高，明显抑制化疗引起的体重减轻、摄食量减少、减轻化疗对血液系统和肝肾功能的毒副作用。结论毛蚶提取物对 NP 方案化疗具有明显的增效减毒作用。
목적：연구모감제취물화 NP 방안화료약물합용후유무증효화감독작용。방법채용인폐암 A549세포주제비라서이식류모형，통과검측억류솔、체중、섭식량、혈액학화혈액생화학등지표，전면평개모감제취물화NP 화료방안합용후적증효감독작용。결과모감제취물（125、250、500 mg／kg， i．g）여 NP 화료방안합용비단용NP 화료방안억류솔명현제고，명현억제화료인기적체중감경、섭식량감소、감경화료대혈액계통화간신공능적독부작용。결론모감제취물대 NP 방안화료구유명현적증효감독작용。
Objective To investigate the synergism and attenuation effects of Scapharca Subcrenata Extraction on NP chemotherapy in model mice.Methods The models of nude mice were induced with A549 cell line xenograft.The tumor inhibiting rates, body weight, food intake, hematology and blood biochemistry index were determined to evaluate the synergism and attenuation effects of Scapharca Subcrenata Extraction (125、250、500 mg/kg, i.g) on NP chemotherapy. Results Compared with NP chemotherapy group, the tumor inhibiting rates, body weight, food intake, white blood cell number were increased and glutamate pyruvate transaminase, glutamic oxalacetic transaminase and urea nitrogen were decreased markedly in NP chemotherapy plus Scapharca Subcrenata Extraction groups. Conclusion Scapharca Subcrenata Extraction has a remarkable synergism and attenuation effects on NP chemotherapy.