中国感染与化疗杂志
中國感染與化療雜誌
중국감염여화료잡지
CHINESE JOURNAL OF INFECTION AND CHEMOTHERAPY
2015年
3期
264-268
,共5页
细菌耐药性监测%药物敏感性试验%广泛耐药菌%超广谱b内酰胺酶
細菌耐藥性鑑測%藥物敏感性試驗%廣汎耐藥菌%超廣譜b內酰胺酶
세균내약성감측%약물민감성시험%엄범내약균%초엄보b내선알매
bacterial resistance surveillance%antimicrobial susceptibility testing%extensively drug-resistant bacteria%extended-spectrum beta-lactamase
目的：了解2013年上海市青浦地区临床分离的革兰阴性菌对抗菌药物的敏感性。方法采用自动化仪器对该地区2所医院临床分离的革兰阴性菌进行药敏试验，采用CLSI 2013年版标准判断结果。结果总计1376株革兰阴性菌中，大肠埃希菌、克雷伯菌属和奇异变形杆菌中产超广谱β内酰胺酶（ESBL ）菌株的检出率分别为66．7％、28．7％和12．5％。产ESBL菌株对临床常用抗菌药物的耐药率均高于非产ESBL菌株。肠杆菌科细菌对碳青霉烯类抗生素仍高度敏感，对亚胺培南和阿米卡星的总耐药率分别为4．2％和6．8％。铜绿假单胞菌和不动杆菌属对亚胺培南的耐药率分别为17．1％、36．0％。大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌和铜绿假单胞菌中有少数菌株对所有测试的药物耐药。结论细菌耐药性仍对临床构成严重威胁，应引起临床关注。
目的：瞭解2013年上海市青浦地區臨床分離的革蘭陰性菌對抗菌藥物的敏感性。方法採用自動化儀器對該地區2所醫院臨床分離的革蘭陰性菌進行藥敏試驗，採用CLSI 2013年版標準判斷結果。結果總計1376株革蘭陰性菌中，大腸埃希菌、剋雷伯菌屬和奇異變形桿菌中產超廣譜β內酰胺酶（ESBL ）菌株的檢齣率分彆為66．7％、28．7％和12．5％。產ESBL菌株對臨床常用抗菌藥物的耐藥率均高于非產ESBL菌株。腸桿菌科細菌對碳青黴烯類抗生素仍高度敏感，對亞胺培南和阿米卡星的總耐藥率分彆為4．2％和6．8％。銅綠假單胞菌和不動桿菌屬對亞胺培南的耐藥率分彆為17．1％、36．0％。大腸埃希菌、肺炎剋雷伯菌、鮑曼不動桿菌和銅綠假單胞菌中有少數菌株對所有測試的藥物耐藥。結論細菌耐藥性仍對臨床構成嚴重威脅，應引起臨床關註。
목적：료해2013년상해시청포지구림상분리적혁란음성균대항균약물적민감성。방법채용자동화의기대해지구2소의원림상분리적혁란음성균진행약민시험，채용CLSI 2013년판표준판단결과。결과총계1376주혁란음성균중，대장애희균、극뢰백균속화기이변형간균중산초엄보β내선알매（ESBL ）균주적검출솔분별위66．7％、28．7％화12．5％。산ESBL균주대림상상용항균약물적내약솔균고우비산ESBL균주。장간균과세균대탄청매희류항생소잉고도민감，대아알배남화아미잡성적총내약솔분별위4．2％화6．8％。동록가단포균화불동간균속대아알배남적내약솔분별위17．1％、36．0％。대장애희균、폐염극뢰백균、포만불동간균화동록가단포균중유소수균주대소유측시적약물내약。결론세균내약성잉대림상구성엄중위협，응인기림상관주。
Objective To investigate the antibiotic resistance in clinical strains of gram‐negative bacteria isolated from the hospitals in Qingpu District from January through December during 2013 .Methods Antimicobial susceptibility testing was carried out for the gram‐negative isolates according to an agreed protocol using automated system .Results were interpreted according to CLSI 2013 breakpoints .Results A total of 1 376 clinical isolates were included in this analysis . The overall prevalence of ESBLs‐producing srains was 66 .7% in E .coli ,28 .7% in K lebsiella spp .and 12 .5% in P .mirabilis .ESBL‐positive strains were more resistant to antimicrobial agents than ESBL‐negative strains . Enterobacteriaceae strains were still highly susceptible to carbapenem antibiotics .Overall ,4 .2% and 6 .8% of the Enterobacteriaceae strains were resistant to imipenem and amikacin ,respectively .About 17 .1% of the P .aeruginosa strains and 36 .0% of the Acinetobacter spp .strains were resistant to imipenem .A few extensively drug‐resistant strains were identified in E .coli ,K .pneumoniae ,A .baumannii and P . aeruginosa .Conclusions Antibicotic resistance is a serious threat to clinical practice .Management and control of extensively drug‐resistant bacteria is a great concern of clinicians .
