CAJ | 학술논문

目的：探讨人类白细胞抗原G( human leukocyte antigen-G, HLA-G)在卵巢浆液性癌( ovarian serous carcinoma, OSC)中的表达及意义。方法运用免疫组化EnVision法检测108例OSC中HLA-G的表达,分析其与临床病理特征的关系。结果 OSC中HLA-G阳性率为58．33%(63/108),HLA-G表达与肿瘤淋巴结转移、复发、发生部位、FIGO分期和MDACC分级相关(P<0．05)。生存分析显示,HLA-G阳性组生存期明显低于阴性组(P=0．015),HLA-G表达是影响预后的重要因素(P=0．01)。结论 HLA-G表达提示为晚期高级别OSC,且患者预后较差,检测HLA-G表达可辅助鉴别诊断高、低级别浆液性癌。
목적：탐토인류백세포항원G( human leukocyte antigen-G, HLA-G)재란소장액성암( ovarian serous carcinoma, OSC)중적표체급의의。방법운용면역조화EnVision법검측108례OSC중HLA-G적표체,분석기여림상병리특정적관계。결과 OSC중HLA-G양성솔위58．33%(63/108),HLA-G표체여종류림파결전이、복발、발생부위、FIGO분기화MDACC분급상관(P<0．05)。생존분석현시,HLA-G양성조생존기명현저우음성조(P=0．015),HLA-G표체시영향예후적중요인소(P=0．01)。결론 HLA-G표체제시위만기고급별OSC,차환자예후교차,검측HLA-G표체가보조감별진단고、저급별장액성암。
Purpose To investigate the expression and significance of HLA-G in ovarian serous carcinoma ( OSC) . Methods HLA-G antigen was immunohistochemically labeled on paraffin-embedded sections of 108 OSCs. The relationship between HLA-G expression and the clinicopathologic parameters was studied. Results The positive expression of HLA-G was observed in 58. 33% (63/108) of OSC tissues. Positive expression of HLA-G was significantly related with lymph node metastasis, recurrence, occurrence site, FIGO stage and MDACC grading system (P<0. 05). In survival analysis, the expression of HLA-G was significantly relevant to prognosis (P=0. 015). Multivariate Cox analysis showed the expression of HLA-G was an important prognosis factor of OSC (P=0. 01). Con-clusion The positive expression of HLA-G could predict high grade and advanced stage of OSC as well as poor prognosis. Also it could distinguish high-grade OSC from low-grade OSC.