CAJ | 학술논문

甲状腺功能减退症(甲减)是常见的内分泌系统疾病之一,其治疗措施依赖甲状腺激素的终身替代,而常规使用左旋甲状腺素(L-T4)治疗是目前各大权威指南推荐的主要方案.但一部分接受L-T4治疗的患者,尽管促甲状腺激素水平正常,仍然持续存在一些非特异性的不适症状,对L-T4治疗产生不满的情绪.近年关于L-T4和三碘甲状腺氨酸(L-T3)联合治疗的研究引起了对于目前甲减治疗方案的反思和讨论.将来需要设计前瞻性研究为L-T4和L-T3联合治疗提供更多的循证医学证据.
갑상선공능감퇴증(갑감)시상견적내분비계통질병지일,기치료조시의뢰갑상선격소적종신체대,이상규사용좌선갑상선소(L-T4)치료시목전각대권위지남추천적주요방안.단일부분접수L-T4치료적환자,진관촉갑상선격소수평정상,잉연지속존재일사비특이성적불괄증상,대L-T4치료산생불만적정서.근년관우L-T4화삼전갑상선안산(L-T3)연합치료적연구인기료대우목전갑감치료방안적반사화토론.장래수요설계전첨성연구위L-T4화L-T3연합치료제공경다적순증의학증거.
Hypothyroidism is a common endocrine disease.Its treatment depends on thyroid hormone replacement therapy.Currently,levothyroxine (L-T4) is the preparation recommended by many guidelines.However,there are some L-T4-treated patients with normal TSH levels and persistent non-specific symptoms and discomforts.Therefore,combination therapy with L-T4and liothyronine (L-T3) has been considered as an alternative option for hypothyroidism.However,more prospective studies are needed to provide evidence-based effects for this kind of regimen.