CAJ | 학술논문

探讨胰岛素与口服降糖药物治疗对2型糖尿病患者抑郁情绪的影响.随机抽取江苏省中医院内分泌科门诊及住院的2型糖尿病患者283例,使用自行设计的问卷和Zung抑郁自评量表(SDS)开展横断面调查.利用t检验或x2比较不同治疗方案组患者的基本情况.应用logistic回归分析治疗方案与抑郁情绪的关系.结果显示43.1％的2型糖尿病患者存在不同程度的抑郁症状.与口服药物组相比,胰岛素组存在抑郁的比例更高(胰岛素组53.5％,口服药物组30.5％;P＜0.01),SDS得分更高[胰岛素组(51.7±12.4)分,口服药物组(44.8±10.6)分;P＜0.01].通过校正年龄、性别、体重指数、糖尿病病程、并发症及HbA1C等多因素后,胰岛素组抑郁发生率仍高于口服药物组(OR=4.218,95％ CI1.764～13.285,P=0.004).胰岛素治疗是2型糖尿病患者抑郁发生的独立危险因素,有必要对此类患者加强心理支持.
탐토이도소여구복강당약물치료대2형당뇨병환자억욱정서적영향.수궤추취강소성중의원내분비과문진급주원적2형당뇨병환자283례,사용자행설계적문권화Zung억욱자평량표(SDS)개전횡단면조사.이용t검험혹x2비교불동치료방안조환자적기본정황.응용logistic회귀분석치료방안여억욱정서적관계.결과현시43.1％적2형당뇨병환자존재불동정도적억욱증상.여구복약물조상비,이도소조존재억욱적비례경고(이도소조53.5％,구복약물조30.5％;P＜0.01),SDS득분경고[이도소조(51.7±12.4)분,구복약물조(44.8±10.6)분;P＜0.01].통과교정년령、성별、체중지수、당뇨병병정、병발증급HbA1C등다인소후,이도소조억욱발생솔잉고우구복약물조(OR=4.218,95％ CI1.764～13.285,P=0.004).이도소치료시2형당뇨병환자억욱발생적독립위험인소,유필요대차류환자가강심리지지.
To explore the depression in type 2 diabetic patients treated with insulin and compared to those treated with oral anti-diabetic drugs.283 type 2 diabetics were seclected randomly from outpatient and inpatient departments of endocrionology in Jiangsu Province Hospital of Traditional Chinese Medicine,with the self-designed questionnaire and Zung self-rating depression scale to conduct the survey.Comparisons between the two groups were carried out with t-test or x2 test for quantitative and qualitative data,respectively.Logistic regression were used for the analysis of the relationship between the therapeutic regimen and depression.Overall,43.1％ of the type 2 diabetic subjects showed depressive symptoms in different degrees.Compared to the oral drug group,the insulin group showed a significantly higher prevalence of depressive symptoms (insulin group,53.5％,oral drug group,30.5％;P＜0.01)and higher self-rating depression scale scores (insulin group,51.7 ± 12.4,oral drug group,44.8 ± 10.6;P＜0.01).Moreover,after an adjustment for age,sex,body mass index,diabetic duration,complications,HbA1Cand so on,the insulin group showed a significantly higher frequency of depression (OR=4.218,95％ CI 1.764-13.285,P=0.004),compared to the oral drug group.The data showed that insulin treatment is an independent risk factor to the presence of depressive symptoms in type 2 diabetics,and it is necessary to pay more attention to their psychological support.