CAJ | 학술논문

建立亚临床甲状腺功能减退(SCH)大鼠模型,分为SCH组、左旋甲状腺素(L-T4)治疗组和对照组.L-L治疗组总胆固醇和内皮素水平低于SCH组,差异有统计学意义[(1.29±0.05对2.38±0.55)mmol/L,(98.54±32.43对160.62±37.25)nmol/L,均P＜0.05].与SCH组相比,L-T4治疗组一氧化氮、左心室收缩压和腹主动脉血流均升高(P＜0.05).提示L-T4可以改善SCH的内皮功能及血流动力学改变.
건립아림상갑상선공능감퇴(SCH)대서모형,분위SCH조、좌선갑상선소(L-T4)치료조화대조조.L-L치료조총담고순화내피소수평저우SCH조,차이유통계학의의[(1.29±0.05대2.38±0.55)mmol/L,(98.54±32.43대160.62±37.25)nmol/L,균P＜0.05].여SCH조상비,L-T4치료조일양화담、좌심실수축압화복주동맥혈류균승고(P＜0.05).제시L-T4가이개선SCH적내피공능급혈류동역학개변.
Established rat models with subclinical hypothyroidism (SCH) were divided into three groups:subclinical hypothyroid(SCH),SCH treated with levothyroxine (L-T4),and control group.The L-T4 group displayed lowered total cholesterol and endothelin levels compared with the SCH group[(1.29 ±0.05 vs 2.38 ±0.55) mmol/L,(98.54 ± 32.43 vs 160.62 ±37.25) nmol/L,both P＜0.05].Nitric oxide levels,left ventricular systolic pressure,and blood flow in abdominal aorta were significantly higher in the L-T4 group than those in the SCH group.The results of this study indicate that L-T4 treatment may improve endothclial dysfunction and hemodynamic changes in rats with SCH.