CAJ | 학술논문

肿瘤循环DNA的变异检测可分为定量和定性两种:前者主要检测循环DNA(血清或血浆)的总量,后者主要检测血清或血浆中肿瘤特异性基因的改变,如基因突变、抑癌基因的甲基化及微卫星变异等.两者均可反映肿瘤的存在和严重程度.本文现就肝细胞癌患者肿瘤循环DNA的变异检测及有关临床意义作一简要综述.
종류순배DNA적변이검측가분위정량화정성량충:전자주요검측순배DNA(혈청혹혈장)적총량,후자주요검측혈청혹혈장중종류특이성기인적개변,여기인돌변、억암기인적갑기화급미위성변이등.량자균가반영종류적존재화엄중정도.본문현취간세포암환자종류순배DNA적변이검측급유관림상의의작일간요종술.
Mutations detection of circulating tumor DNA can be divided into quantitative and qualitative classifications:the forumer mainly detects the total amount of circulating DNA (serum or plasma),whereas the latter mainly detects the specific genetic variations in serum or plasma DNA,such as gene mutations,methylations of tumor suppressor genes,and microsatellite alterations,etc.Both of them may reflect the tumor presence and disease severity.In this paper,mutations detection and its clinical significance of circulating tumor DNA in patients with hepatocellular carcinoma are reviewed.