CAJ | 학술논문

目的探讨手术联合阿苯达唑脂质体治疗晚期泡型肝包虫病的效果及临床价值.方法回顾性分析2002年1月至2013年1 1月71例晚期泡型肝包虫病患者临床资料.根据手术方式的不同及是否联合阿苯达唑脂质体治疗将患者分为四组进行分析比较.结果术后随访时间最短5个月,最长44个月,单纯减体手术治疗组病死率为82.3％ (14/17);减体手术+阿苯达唑治疗组病死率为52.3％(11/21);单纯根治手术治疗组病死率为28.5％ (4/14);根治手术+阿苯达唑治疗组病死率为21.1％(4/19).根治术+阿苯达唑治疗组病死率与根治手术组及减体手术+阿苯达唑治疗组比较差异有统计学意义(P＜0.05);单纯根治手术组病死率与减体手术+阿苯达唑治疗组比较差异无统计学差异(P＞0.05);单纯减体手术治疗组病死率与减体手术+阿苯达唑治疗组以及单纯根治手术组与根治术+阿苯达唑治疗组比较差异有统计学意义(P＜0.05).结论手术联合阿苯达唑脂质体治疗晚期泡型肝包虫病,可降低或减少患者术后复发的可能,提高患者生活质量和延长生命.
목적 탐토수술연합아분체서지질체치료만기포형간포충병적효과급림상개치.방법 회고성분석2002년1월지2013년1 1월71례만기포형간포충병환자림상자료.근거수술방식적불동급시부연합아분체서지질체치료장환자분위사조진행분석비교.결과 술후수방시간최단5개월,최장44개월,단순감체수술치료조병사솔위82.3％ (14/17);감체수술+아분체서치료조병사솔위52.3％(11/21);단순근치수술치료조병사솔위28.5％ (4/14);근치수술+아분체서치료조병사솔위21.1％(4/19).근치술+아분체서치료조병사솔여근치수술조급감체수술+아분체서치료조비교차이유통계학의의(P＜0.05);단순근치수술조병사솔여감체수술+아분체서치료조비교차이무통계학차이(P＞0.05);단순감체수술치료조병사솔여감체수술+아분체서치료조이급단순근치수술조여근치술+아분체서치료조비교차이유통계학의의(P＜0.05).결론 수술연합아분체서지질체치료만기포형간포충병,가강저혹감소환자술후복발적가능,제고환자생활질량화연장생명.
Objective To investigate the outcomes of surgery combined with albendazole liposomes in the treatment of advanced hepatic alveolar echinococcosis.Methods This is a retrospective study on 71 patients with advanced hepatic alveolar echinococcosis treated from January 2002 to November 2013.The patients were divided into 4 groups according to the surgical methods and whether surgery was combined with albendazole liposomes.Results On follow-up from 5 ～ 44 months,the mortality rates for the volume-reduction surgery group was 82.3％,the volume-reduction surgery + albendazole group 52.3％,the radical operation group 28.5％,and the radical operation + albendazole group 21.1％.The mortality rate of the radical operation + albendazole group,when compared with the radical operation group and the volume-reduction surgery + albendazole group was significantly different (P ＜ 0.05).The mortality rate of the radical operation group,when compared with the volume-reduction surgery + albendazole group showed no significant difference (P ＞ 0.05).The mortality rate of the volume-reduction surgery group,when compared with the volume-reduction surgery + albendazole group,the radical operation group,and the radical operation + albendazole group was significantly different (P ＜ 0.05).Conclusions The treatment of radical operation combined with albendazole liposomes for advanced hepatic alveolar echinococcosis reduced recurrence,improved quality of life and prolonged survival.It is a feasible method to treat these patients.