CAJ | 학술논문

目的研究肌切蛋白(scinderin)在原发性肝细胞癌(HCC)及门静脉癌栓(PVTT)组织中的表达,探讨其在HCC发生和发展中的作用及与预后的关系.方法采用免疫组织化学方法检测33例患者肝癌组织、癌旁组织及PVTT组织中scinderin的表达.分析scinderin表达与相关临床病理指标及预后的关系.结果 scinderin在癌旁组织、HCC组织及PVTT组织中的阳性表达率分别为69.7％ (23/33)、45.5％(15/33)及24.2％(8/33).HCC组织阳性表达率明显低于癌旁组织(P＜0.05);PVTT组织阳性表达率明显低于HCC组织(P＜0.05).HCC组织中scinderin的表达与肿瘤大小、有无包膜及血中甲胎蛋白水平呈显著相关(P＜0.05);scinderin阳性患者术后无复发生存期(RFS)及总体生存期(OS)均好于scinderin阴性组(P＜0.05).多因素分析显示,scinderin是影响HCC患者术后RFS和OS的独立风险因素.结论与癌旁组织相比,scinderin在HCC组织及PVTT组织中表达降低,其表达与HCC复发及预后存在相关性.scinderin有望作为判断HCC伴PVTT患者预后的指标.
목적 연구기절단백(scinderin)재원발성간세포암(HCC)급문정맥암전(PVTT)조직중적표체,탐토기재HCC발생화발전중적작용급여예후적관계.방법 채용면역조직화학방법검측33례환자간암조직、암방조직급PVTT조직중scinderin적표체.분석scinderin표체여상관림상병리지표급예후적관계.결과 scinderin재암방조직、HCC조직급PVTT조직중적양성표체솔분별위69.7％ (23/33)、45.5％(15/33)급24.2％(8/33).HCC조직양성표체솔명현저우암방조직(P＜0.05);PVTT조직양성표체솔명현저우HCC조직(P＜0.05).HCC조직중scinderin적표체여종류대소、유무포막급혈중갑태단백수평정현저상관(P＜0.05);scinderin양성환자술후무복발생존기(RFS)급총체생존기(OS)균호우scinderin음성조(P＜0.05).다인소분석현시,scinderin시영향HCC환자술후RFS화OS적독립풍험인소.결론 여암방조직상비,scinderin재HCC조직급PVTT조직중표체강저,기표체여HCC복발급예후존재상관성.scinderin유망작위판단HCC반PVTT환자예후적지표.
Objective To examine the expression of scinderin in primary hepatocellular carcinoma (HCC) and its paired portal vein tumor thrombus (PVTT) tissues; and to explore its role in the development of HCC and its relationship with prognosis of HCC.Methods Immunohistochemistry was used to detect the expressions of scinderin in tumor-adjacent normal liver tissues,HCC tissues and PVTT tissues from 33 patients.Results The positive expression rates of scinderin in tumor-adjacent normal tissues,HCC tissues and PVTT tissues were 69.7％ (23/33),45.5％ (15/33) and 24.2％ (8/33) respectively.A significantly lower scinderin expression was found in HCC tissues when compared with tumor-adjacent normal tissues (P ＜ 0.05).Also,the expression of scinderin in PVTT tissues was significantly lower than in HCC tissues (P ＜ 0.05).The expression of scinderin in HCC tissues significantly correlated with tumor size,absence of tumor capsule and serum AFP (P ＜0.05).The recurrence-free survival (RFS) and overall survival (OS) of Scinderin-positive patients were significantly longer than Scinderin-negative patients (P ＜ 0.05).Multivariate analysis revealed scinderin expression level to be an independent risk factor affecting RFS and OS after curative resection.Conclusions Scinderin was down-regulated in HCC tissues and PVTT tissues when compared with its paired tumor-adjacent normal liver tissues.The expression level of scinderin correlated with HCC recurrence and prognosis.Scinderin can be used as an indicator of prognosis of HCC patients with PVTT.