CAJ | 학술논문

多中心随机对照研究能在较短时间内收集较多的受试者,避免单一研究机构可能存在的局限性,所得到的结论可信度大并且有更广泛的意义,对于临床实践具有较强的指导性.是评价临床研究最科学、最可靠、最具可信度的方法.但我国眼底病临床研究中,由医务工作者发起,以临床工作面临的问题和挑战为线索进行多中心随机对照研究不多,大量是未设立对照的“临床回顾性研究”和一些科研设计、样本代表性以及偏倚控制方面存在缺陷的“前瞻性研究”.这些研究结果的论证强度较低,临床参考价值不大,学术意义非常有限.中华医学会眼科学分会眼底病学组已经在开放的眼底病临床研究平台搭建、与国际接轨的多中心随机对照研究机制推广方面开始了卓有成效地积极探索,加强多中心随机对照研究,促进眼底病临床研究水平的提高是我们应有的责任和担当.接下来是需要我们每一个人增强意识,提升水平,踊跃参与.
다중심수궤대조연구능재교단시간내수집교다적수시자,피면단일연구궤구가능존재적국한성,소득도적결론가신도대병차유경엄범적의의,대우림상실천구유교강적지도성.시평개림상연구최과학、최가고、최구가신도적방법.단아국안저병림상연구중,유의무공작자발기,이림상공작면림적문제화도전위선색진행다중심수궤대조연구불다,대량시미설립대조적“림상회고성연구”화일사과연설계、양본대표성이급편의공제방면존재결함적“전첨성연구”.저사연구결과적론증강도교저,림상삼고개치불대,학술의의비상유한.중화의학회안과학분회안저병학조이경재개방적안저병림상연구평태탑건、여국제접궤적다중심수궤대조연구궤제추엄방면개시료탁유성효지적겁탐색,가강다중심수궤대조연구,촉진안저병림상연구수평적제고시아문응유적책임화담당.접하래시수요아문매일개인증강의식,제승수평,용약삼여.
Multicenter randomized controlled studies can recruit more subjects in a relatively short period of time,avoiding the bias of single research institution studies,resulting in reliable conclusions and providing strong guidance to clinical practice.They are the most scientific and most reliable methods to evaluate clinical researches.However,there are few multicenter clinical trials in China as Chinese doctors are often trapped in difficulties in clinical research,including imperfect research system,lack of experience,capital investment deficient,the tension in the doctor-patient relationship and so on.Although the above problems are related to medical system architecture of our country in a certain extent,compared with the overseas,we also have our own advantages,such as resource of our patients,doctors,and diseases type.Pay attention to discovering of new type of diseases,looking for genetics discipline,and exploring new medical technology is an important task of clinical research.We have plenty of high level ophthalmology centers at present,which provide favorable conditions for launching multi-center clinical trial studies.We have good reasons to believe that,if we can effectively exploit the resources in our hands,carefully observe and discover clinical problems,there will be more convincing clinical results present in the world after bring up hypothesis boldly while prove it conscientiously and carefully.