中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2015年
3期
235-239
,共5页
中心性浆液性脉络膜视网膜病变/治疗%体层摄影术,光学相干
中心性漿液性脈絡膜視網膜病變/治療%體層攝影術,光學相榦
중심성장액성맥락막시망막병변/치료%체층섭영술,광학상간
Central serous chorioretinopathy/therapy%Tomography,optical coherence
目的 观察慢性中心性浆液性脉络膜视网膜病变(CSC)半剂量光敏剂光动力疗法(PDT)治疗后黄斑部内、外层视网膜厚度变化特点.方法 临床检查确诊的慢性CSC患者19例19只眼(治疗组)纳入研究.其中,男性15例15只眼,女性4例4只眼;平均年龄(48.18±9.46);病程＞6个月.均为首次接受半剂量光敏剂PDT治疗者.所有患者行最佳矫正视力(BCVA)、裂隙灯显微镜、彩色眼底照相、荧光素眼底血管造影联合吲哚青绿血管造影、傅立叶光相干断层扫描(FD-OCT)检查.BCVA检查采用国际标准对数视力表,结果转换为最小分辨角对数(logMAR)视力记录.患眼平均logMAR BCVA为0.39±0.30.选择同期健康体检者24名24只眼作为对照组.所有受检眼采用FD-OCT仪测量距黄斑中心凹1(中心凹)、3(旁中心凹)、5(中心凹周围)mm区域4个象限的内、外层视网膜厚度.治疗后1、4、12周行FD-OCT检查,观察治疗后不同时间点内、外层视网膜厚度变化情况.Pearson法分析logMAR BCVA与治疗后各时间点视网膜厚度的相关性.结果 治疗后1、4、12周,治疗组中心凹内(F＝13.814、10.095、4.689)、外(F=9.354、5.878、3.978)层视网膜厚度均较治疗前降低,差异有统计学意义(P＜0.05).治疗后12周,治疗组与对照组比较,中心凹外层视网膜厚度差异有统计学意义(t＝-3.725,P＜0.05);旁中心凹内、外层视网膜厚度差异有统计学意义(t＝-3.198、-2.722,P＜0.05).相关性分析结果显示,治疗后1周,中心凹外层视网膜厚度与logMAR BCVA呈显著正相关(r=0.465,P＜0.05);治疗后12周,中心凹、旁中心凹外层视网膜厚度与logMAR BCVA呈显著负相关(r＝-0.728、-0.687,P＜0.05).结论 半剂量光敏剂PDT治疗后黄斑部内、外层视网膜厚度普遍下降.
目的 觀察慢性中心性漿液性脈絡膜視網膜病變(CSC)半劑量光敏劑光動力療法(PDT)治療後黃斑部內、外層視網膜厚度變化特點.方法 臨床檢查確診的慢性CSC患者19例19隻眼(治療組)納入研究.其中,男性15例15隻眼,女性4例4隻眼;平均年齡(48.18±9.46);病程＞6箇月.均為首次接受半劑量光敏劑PDT治療者.所有患者行最佳矯正視力(BCVA)、裂隙燈顯微鏡、綵色眼底照相、熒光素眼底血管造影聯閤吲哚青綠血管造影、傅立葉光相榦斷層掃描(FD-OCT)檢查.BCVA檢查採用國際標準對數視力錶,結果轉換為最小分辨角對數(logMAR)視力記錄.患眼平均logMAR BCVA為0.39±0.30.選擇同期健康體檢者24名24隻眼作為對照組.所有受檢眼採用FD-OCT儀測量距黃斑中心凹1(中心凹)、3(徬中心凹)、5(中心凹週圍)mm區域4箇象限的內、外層視網膜厚度.治療後1、4、12週行FD-OCT檢查,觀察治療後不同時間點內、外層視網膜厚度變化情況.Pearson法分析logMAR BCVA與治療後各時間點視網膜厚度的相關性.結果 治療後1、4、12週,治療組中心凹內(F＝13.814、10.095、4.689)、外(F=9.354、5.878、3.978)層視網膜厚度均較治療前降低,差異有統計學意義(P＜0.05).治療後12週,治療組與對照組比較,中心凹外層視網膜厚度差異有統計學意義(t＝-3.725,P＜0.05);徬中心凹內、外層視網膜厚度差異有統計學意義(t＝-3.198、-2.722,P＜0.05).相關性分析結果顯示,治療後1週,中心凹外層視網膜厚度與logMAR BCVA呈顯著正相關(r=0.465,P＜0.05);治療後12週,中心凹、徬中心凹外層視網膜厚度與logMAR BCVA呈顯著負相關(r＝-0.728、-0.687,P＜0.05).結論 半劑量光敏劑PDT治療後黃斑部內、外層視網膜厚度普遍下降.
목적 관찰만성중심성장액성맥락막시망막병변(CSC)반제량광민제광동력요법(PDT)치료후황반부내、외층시망막후도변화특점.방법 림상검사학진적만성CSC환자19례19지안(치료조)납입연구.기중,남성15례15지안,녀성4례4지안;평균년령(48.18±9.46);병정＞6개월.균위수차접수반제량광민제PDT치료자.소유환자행최가교정시력(BCVA)、렬극등현미경、채색안저조상、형광소안저혈관조영연합신타청록혈관조영、부립협광상간단층소묘(FD-OCT)검사.BCVA검사채용국제표준대수시력표,결과전환위최소분변각대수(logMAR)시력기록.환안평균logMAR BCVA위0.39±0.30.선택동기건강체검자24명24지안작위대조조.소유수검안채용FD-OCT의측량거황반중심요1(중심요)、3(방중심요)、5(중심요주위)mm구역4개상한적내、외층시망막후도.치료후1、4、12주행FD-OCT검사,관찰치료후불동시간점내、외층시망막후도변화정황.Pearson법분석logMAR BCVA여치료후각시간점시망막후도적상관성.결과 치료후1、4、12주,치료조중심요내(F＝13.814、10.095、4.689)、외(F=9.354、5.878、3.978)층시망막후도균교치료전강저,차이유통계학의의(P＜0.05).치료후12주,치료조여대조조비교,중심요외층시망막후도차이유통계학의의(t＝-3.725,P＜0.05);방중심요내、외층시망막후도차이유통계학의의(t＝-3.198、-2.722,P＜0.05).상관성분석결과현시,치료후1주,중심요외층시망막후도여logMAR BCVA정현저정상관(r=0.465,P＜0.05);치료후12주,중심요、방중심요외층시망막후도여logMAR BCVA정현저부상관(r＝-0.728、-0.687,P＜0.05).결론 반제량광민제PDT치료후황반부내、외층시망막후도보편하강.
Objective To observe the characteristic variation of the patients' inner and outer retina who had chronic central serous chorioretinopathy (CSC) after being treated of photodynamic therapy (PDT).Methods Nineteen patients with chronic CSC were recruited,including 15 eye of men and 4 eye of women,logMAR BCVA was 0.1-1.0,0.39 ± 0.30.Meanwhile,24 healthy people were located in the control group.All the patients received PDT for the first time.All subjects including 24 healthy people underwent fourier domain optical coherence tomography (FD-OCT).Retinal thickness were investigated before PDT and 1,4,12,20 weeks after PDT respectively.Data were recorded including inner layer and outer layer.Retinal thickness were compared in fovea (1 mm),parafovea (3 mm)and perifovea(5 mm).Paired-samples t test was used to compare retinal thickness before and after PDT.The statistical differences of patients and control group were evaluated by independent-samples t test.The correlations between the best logMAR corrected visual acuity (BCVA) was analyzed by Pearson statistical analyses.Results The inner(F=13.814,10.095,4.689) and outer(F＝ 9.354,5.878,3.978) layer fovea thickness of CSC subjects in 1,4,12 week was thinner,the difference was statistically significant (P＜0.05).The outer layer fovea thickness at P12 (t =-3.725),parafovea of inner and outer retinal (t =-3.198,-2.722) was reduced when compared with control group,and differences have statistical sense,respectively (P＜0.05).There was correlation between logMAR BCVA and outer retinal thickness in fovea and parafovea (r =0.465,-0.728,-0.687; P＜0.05).Conclusion In our study,the inner and outer layer retinal thickness decreased generally after the first time PDT in CSC patients.
