CAJ | 학술논문

目的观察急性中心性浆液性脉络膜视网膜病变(CSC)患眼短波长自身荧光(SW-AF)、近红外自身荧光(NIR-AF)、频域光相干断层扫描(SD-OCT)的影像特征.方法回顾性病例系列研究.临床检查确诊的急性CSC患者76例82只眼纳入研究.其中,男性50例56只眼,女性26例26只眼.平均年龄(41.32±7.37)岁.平均病程(0.47±1.73)个月.均行最佳矫正视力、裂隙灯显微镜、间接检眼镜、荧光素眼底血管造影(FFA)、NIR-AF、SW-AF、SD-OCT检查.对比分析同一患眼的NIR-AF、SW-AF、SD-OCT及FFA的影像特征.结果 SD-OCT检查结果显示,所有患眼均存在视网膜色素上皮(RPE)脱离病灶,且与FFA检查所见的RPE渗漏部位相对应.RPE渗漏部位NIR-AF表现为局灶性弱荧光,SW-AF则表现为正常荧光.所有患眼视网膜神经上皮盘状脱离区域NIR-AF亮度较周围正常组织减弱.SW-AF表现为与视网膜神经上皮盘状脱离范围一致的弱荧光75只眼.FFA检查结果显示,82只眼中,除RPE荧光素渗漏外,可见簇状透见荧光45只眼.NIR-AF表现为与FFA检查所见的簇状透见荧光形态、范围一致的弱荧光45只眼.SW-AF表现为与FFA检查所见的簇状透见荧光形态、范围一致的弱荧光27只眼;弱荧光范围及数量较NIR-AF明显减少18只眼.结论急性CSC患眼均存在局限性RPE脱离;视网膜神经上皮脱离区、RPE脱离区及RPE脱色素区NIR-AF均呈现为弱荧光;多数患眼视网膜神经上皮脱离区及RPE脱色素区SW-AF呈现为弱荧光.
목적 관찰급성중심성장액성맥락막시망막병변(CSC)환안단파장자신형광(SW-AF)、근홍외자신형광(NIR-AF)、빈역광상간단층소묘(SD-OCT)적영상특정.방법 회고성병례계렬연구.림상검사학진적급성CSC환자76례82지안납입연구.기중,남성50례56지안,녀성26례26지안.평균년령(41.32±7.37)세.평균병정(0.47±1.73)개월.균행최가교정시력、렬극등현미경、간접검안경、형광소안저혈관조영(FFA)、NIR-AF、SW-AF、SD-OCT검사.대비분석동일환안적NIR-AF、SW-AF、SD-OCT급FFA적영상특정.결과 SD-OCT검사결과현시,소유환안균존재시망막색소상피(RPE)탈리병조,차여FFA검사소견적RPE삼루부위상대응.RPE삼루부위NIR-AF표현위국조성약형광,SW-AF칙표현위정상형광.소유환안시망막신경상피반상탈리구역NIR-AF량도교주위정상조직감약.SW-AF표현위여시망막신경상피반상탈리범위일치적약형광75지안.FFA검사결과현시,82지안중,제RPE형광소삼루외,가견족상투견형광45지안.NIR-AF표현위여FFA검사소견적족상투견형광형태、범위일치적약형광45지안.SW-AF표현위여FFA검사소견적족상투견형광형태、범위일치적약형광27지안;약형광범위급수량교NIR-AF명현감소18지안.결론 급성CSC환안균존재국한성RPE탈리;시망막신경상피탈리구、RPE탈리구급RPE탈색소구NIR-AF균정현위약형광;다수환안시망막신경상피탈리구급RPE탈색소구SW-AF정현위약형광.
Objective To observe the imaging features of short-wave length fundus autofluorescence (SW-AF),near-infrared fundus autofluorescence (NIR-AF)and spectral-domain optical coherence tomograph (SD-OCT) in acute central serous chorioretinopathy (CSC).Methods This is a retrospective observational consecutive case series study.Eighty-two eyes with acute CSC from 76 patients were enrolled in this study.There were 50 males (56 eyes) and 26 females (26 eyes),average age was (41.32 ± 7.37) years old,average course of the disease was (0.47 ± 1.73) months.The routine clinical examinations included best corrected visual acuity,slit lamp microscope,indirect ophthalmoscope,fundus fluorescein angiography (FFA),SW-AF,NIR AF and SD-OCT.The imaging features of NIR-AF,SW-AF,SD-OCT and FFA in same eye with acute CSC were analyzed comparatively.Results SD-OCT showed retinal pigment epithelium (RPE) detachment corresponding to RPE leakage point on FFA images in all CSC eyes.RPE leakage points in all eyes corresponding to local hypo-NIR-AF,whereas corresponding to normal SW-AF.NIR-AF demonstrated the area of decreased AF corresponding to serous retinal detachment in all eyes,of which,the area of hypo-SW-AF was consistent with that of sensory retinal detachment in 75 eyes.Except for RPE leaking fluorescein in 82 eyes,FFA showed window defects corresponding to clusters of hypo-NIR-AF in 45 eyes,of which,27 eyes showed hypo-SW-AF appearing concurrently with the locations of window defects of FFA.In 18 eyes,the extent and amount of hypo-SW-AF were less than that of hypo-NIR-AF.Conclusions There was local RPE detachment in all eyes with acute CSC.The locations of sensory retinal detachment,local RPE detachment and RPE depigmentation showed hypo-NIR-AF.The locations of sensory retinal detachment and RPE depigmentation showed hypo-SW-AF in most of acute CSC eyes.