CAJ | 학술논문

目的：探讨双歧杆菌四联活菌片治疗肝硬化腹泻患者的临床疗效以及对肠道sIgA水平和细胞免疫功能的影响。方法选取120例肝硬化腹泻的患者，将其随机分为两组。对照组给予抗病毒、护肝利尿、消炎、解痉和营养支持等常规肝硬化腹泻治疗，观察组则在对照组的基础上减消炎、解痉药加用双歧杆菌四联活菌片治疗。疗程均为4周。观察并比较两组患者的临床治疗效果、肠道sIgA水平变化以及细胞免疫功能的改善情况。结果观察组总有效率为96.67%，显著高于对照组的78.33%（P＜0.05）；治疗后两组患者ALT、AST、TBIL水平均较治疗前明显下降，SIgA水平较治疗前明显上升（P＜0.05），且观察组下降或上升幅度均大于对照组，两组比较差异具有统计学意义（P＜0.05）；观察组治疗后CD4+和CD4+/CD8+比值较治疗前明显升高，且高于对照组，差异有统计学意义（P＜0.05）；CD8+水平与治疗前比较差异无统计学意义（P＞0.05）。结论双歧杆菌四联活菌片治疗肝硬化腹泻疗效显著，可以有效地提高患者肠道sIgA水平，增强患者细胞免疫功能。
목적：탐토쌍기간균사련활균편치료간경화복사환자적림상료효이급대장도sIgA수평화세포면역공능적영향。방법선취120례간경화복사적환자，장기수궤분위량조。대조조급여항병독、호간이뇨、소염、해경화영양지지등상규간경화복사치료，관찰조칙재대조조적기출상감소염、해경약가용쌍기간균사련활균편치료。료정균위4주。관찰병비교량조환자적림상치료효과、장도sIgA수평변화이급세포면역공능적개선정황。결과관찰조총유효솔위96.67%，현저고우대조조적78.33%（P＜0.05）；치료후량조환자ALT、AST、TBIL수평균교치료전명현하강，SIgA수평교치료전명현상승（P＜0.05），차관찰조하강혹상승폭도균대우대조조，량조비교차이구유통계학의의（P＜0.05）；관찰조치료후CD4+화CD4+/CD8+비치교치료전명현승고，차고우대조조，차이유통계학의의（P＜0.05）；CD8+수평여치료전비교차이무통계학의의（P＞0.05）。결론쌍기간균사련활균편치료간경화복사료효현저，가이유효지제고환자장도sIgA수평，증강환자세포면역공능。
Objective To explore the clinical efficacy of bifidobacterium tetravaccine tablets in the treat-ment of cirrhotic patients with diarrhea and its influence on sIgA levels and cellular immune function. Methods One hundred and twenty cirrhotic patients with diarrhea in our hospital were randomly divided into two groups. The patients in control group was treated with antiviral medication, diuresis, nutritional support as well as oth-er conventional treatments, and patients in observation group was treated with bifidobacterium tetravaccine tablets on the basis of the control group. The treatment effect and the changes of intestinal sIgA levels and cel-lular immune function of the two groups were observed and compared. Results After treatment, the total effec-tive rate of observation group was 96.67%, significantly higher than 78.33%in the control group (P<0.05). The levels of ALT, AST, TBIL were significantly decreased than before the treatment, and the level of sIgA was significantly increased when compared with those before the treatment (P<0.05). There was also a signif-icant difference concerning the levels of ALT, AST, TBIL, and sIgA between two groups after the treatment. Levels of CD4+and CD4+/CD8+in the observation group were significantly higher than that in control group (P<0.05). Conclusion Bifidobacterium tetravaccine tablets in the treatment of cirrhotic patients with diarrhea had significant clinical efficacy, could improve the intestinal sIgA level and enhance the cellular immune func-tion of the patients effectively.