CAJ | 학술논문

目的：探讨早期应用参附注射液对老年感染性休克患者血浆脑钠肽（ BNP）水平的影响。方法选取2012年9月—2014年9月玉田县中医医院收治的86例感染性休克患者，随机分为对照组（43例）与参附注射液组（43例）。对照组给予西医综合治疗，参附注射液组在此基础上给予参附注射液治疗。分别在治疗前和治疗后1、3、5d检测血浆BNP水平。结果治疗后参附注射液组好转率高于对照组，差异有统计学意义（ P<0.05）。治疗前两组患者血浆BNP水平比较，差异无统计学意义（ P>0.05）；治疗后1d两组血浆BNP水平比较，差异无统计学意义（ P>0.05），治疗后3、5d参附注射液组的血浆BNP水平低于对照组，差异有统计学意义（ P<0.05）。两组患者治疗前每搏输出量（SV）、心搏出量（CO）、心脏排血指数（CI）及左心室射血分数（LVEF）比较，差异无统计学意义（P>0.05）；治疗后3、5d两组SV、CO、CI及LVEF比较，差异有统计学意义（P<0.05）。结论早期应用参附注射液治疗老感染性休克，可降低患者BNP水平，促进心功能的恢复和患者的转归。
목적：탐토조기응용삼부주사액대노년감염성휴극환자혈장뇌납태（ BNP）수평적영향。방법선취2012년9월—2014년9월옥전현중의의원수치적86례감염성휴극환자，수궤분위대조조（43례）여삼부주사액조（43례）。대조조급여서의종합치료，삼부주사액조재차기출상급여삼부주사액치료。분별재치료전화치료후1、3、5d검측혈장BNP수평。결과치료후삼부주사액조호전솔고우대조조，차이유통계학의의（ P<0.05）。치료전량조환자혈장BNP수평비교，차이무통계학의의（ P>0.05）；치료후1d량조혈장BNP수평비교，차이무통계학의의（ P>0.05），치료후3、5d삼부주사액조적혈장BNP수평저우대조조，차이유통계학의의（ P<0.05）。량조환자치료전매박수출량（SV）、심박출량（CO）、심장배혈지수（CI）급좌심실사혈분수（LVEF）비교，차이무통계학의의（P>0.05）；치료후3、5d량조SV、CO、CI급LVEF비교，차이유통계학의의（P<0.05）。결론조기응용삼부주사액치료로감염성휴극，가강저환자BNP수평，촉진심공능적회복화환자적전귀。
Objective To investigate the influence of early application of Shenfu injection on brain natriuretic peptide ( BNP) in elerdly patients with septic shock. Methods In Yutian County Traditional Chinese Medicine Hospital from Septem-ber 2012 to September 2014,a total of 86 elderly patients with septic shock were selected and randomly divided into Shenfu in-jection group(43 cases)and control group(423 cases). Control group received basic treatment,Shenfu injection group re-ceived Shenfu injection on the basis of control group. BNP was measured before and after 1d,3d,5d of treatment. Results Improvement rate of Shenfu injection group after treatment was higher than control group,the differences were statistically signifi-cant(P<0. 05). There was no statistically significant differences in the BNP level before and after 1d of treatment between the two groups(P>0. 05). There was statistically significant differences in the BNP level after 3d and 5d of treatment between the two groups(P<0. 05). The stroke volume(SV),cardiac output(CO),cardiac ejection fraction(CI)and left ventricular ejection fraction( LVEF)before treatment between the two groups were compared,the differences were not statistically signifi-cant(P>0. 05);SV,CO,CI and LVEF 3d and 5d after treatment between the two groups were compared,the differences were statistically significant(P<0. 05). Conclusion Early application of Shenfu injection can inhibit the BNP in elderly pa-tients with septic shock and improve the prognosis.