临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
15期
31-33
,共3页
姜黄素%微球体
薑黃素%微毬體
강황소%미구체
Curcumin%Microspheres
目的：制备姜黄素自乳化微球，以提高姜黄素的水溶性，进而提高其生物利用度。方法利用溶解度实验和伪三元相图的方法筛选自乳化处方，利用单纯型网格法进行处方优化，并对制备的自乳化微球进行体外性质考察。结果制备的自乳化微球的最大载药量为71.32mg/g，包封率为44.31%，平均粒径为11.33μm，在3种递质中的释放量均超过80%。结论所制备的姜黄素自乳化微球载药量高，包封率、粒径符合要求，能够显著提高姜黄素的释放度。
目的：製備薑黃素自乳化微毬，以提高薑黃素的水溶性，進而提高其生物利用度。方法利用溶解度實驗和偽三元相圖的方法篩選自乳化處方，利用單純型網格法進行處方優化，併對製備的自乳化微毬進行體外性質攷察。結果製備的自乳化微毬的最大載藥量為71.32mg/g，包封率為44.31%，平均粒徑為11.33μm，在3種遞質中的釋放量均超過80%。結論所製備的薑黃素自乳化微毬載藥量高，包封率、粒徑符閤要求，能夠顯著提高薑黃素的釋放度。
목적：제비강황소자유화미구，이제고강황소적수용성，진이제고기생물이용도。방법이용용해도실험화위삼원상도적방법사선자유화처방，이용단순형망격법진행처방우화，병대제비적자유화미구진행체외성질고찰。결과제비적자유화미구적최대재약량위71.32mg/g，포봉솔위44.31%，평균립경위11.33μm，재3충체질중적석방량균초과80%。결론소제비적강황소자유화미구재약량고，포봉솔、립경부합요구，능구현저제고강황소적석방도。
Objective To prepare curcumin album in self-emulsifying microsphere and study its release characteris-tics in vitro. Methods The contents of curcumin was measured by HPLC. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region. In vitro dissolution determination was carried out. Results The largest drug loadings of self-emulsifying microsphere was 71. 32mg/g,the encapsulation efficiency was 44. 31%,the average grain diame-ter was 11. 33μm,and the emission capacity was over 80% in three different mediums,respectively. Conclusion The self-microemulsifying microsphere can be successfully formulated with high drug loading rate and dissolution.
