CAJ | 학술논문

目的：探讨银杏叶片联合阿托伐他汀治疗冠心病心绞痛的临床疗效。方法选择2012年7月—2013年7月于南京农业大学医院及常州市第二人民医院接受治疗的冠心病心绞痛患者82例，随机分为治疗组和对照组，各41例。两组患者均给予常规治疗，对照组在常规治疗基础上给予阿托伐他汀治疗，治疗组在常规治疗基础上给予银杏叶片联合阿托伐他汀治疗。比较两组患者的临床疗效及心电图疗效，治疗前及治疗后1个月、3个月和6个月血脂水平〔总胆固醇（ TC）、三酰甘油（ TG）、低密度脂蛋白胆固醇（ LDL-C）和高密度脂蛋白胆固醇（ HDL-C）〕；治疗6个月后随访心脑血管事件发生情况。结果观察组临床治疗总有效率、心电图治疗总有效率高于对照组，差异有统计学意义（ P<0.05）；治疗后治疗组TC、TG和LDL-C水平低于对照组，差异有统计学意义（ P<0.05）。对两组患者进行为期6个月的随访，对照组患者心绞痛、心肌梗死及心力衰竭的发生率高于治疗组，差异有统计学意义（ P<0.05）。结论银杏叶片联合阿托伐他汀能有效改善患者心绞痛症状，降低患者血脂水平，减少患者脑血管疾病的发生。
목적：탐토은행협편연합아탁벌타정치료관심병심교통적림상료효。방법선택2012년7월—2013년7월우남경농업대학의원급상주시제이인민의원접수치료적관심병심교통환자82례，수궤분위치료조화대조조，각41례。량조환자균급여상규치료，대조조재상규치료기출상급여아탁벌타정치료，치료조재상규치료기출상급여은행협편연합아탁벌타정치료。비교량조환자적림상료효급심전도료효，치료전급치료후1개월、3개월화6개월혈지수평〔총담고순（ TC）、삼선감유（ TG）、저밀도지단백담고순（ LDL-C）화고밀도지단백담고순（ HDL-C）〕；치료6개월후수방심뇌혈관사건발생정황。결과관찰조림상치료총유효솔、심전도치료총유효솔고우대조조，차이유통계학의의（ P<0.05）；치료후치료조TC、TG화LDL-C수평저우대조조，차이유통계학의의（ P<0.05）。대량조환자진행위기6개월적수방，대조조환자심교통、심기경사급심력쇠갈적발생솔고우치료조，차이유통계학의의（ P<0.05）。결론은행협편연합아탁벌타정능유효개선환자심교통증상，강저환자혈지수평，감소환자뇌혈관질병적발생。
Objective To study the clinical efficacy of Ginkgo biloba extract combined with atorvastatin in the treat-ment of coronary heart disease angina. Methods In Nanjing Agricultural University Hospital and the Second People's Hospital of Changzhou from July 2012 to July 2013,a total of 82 coronary heart disease angina patients were selected and randomly divid-ed into control group and treatment group,41 cases in each group. All patients were given conventional therapy,control group were treated with atorvastatin on the basis of conventional therapy,treatment group were treated with Ginkgo biloba extract com-bined with atorvastatin on the basis of conventional therapy,clinical efficacy and electrocardiograph( ECG)efficacy,before and 1 month,3 months and 6 months after treatment serum lipid level〔total cholesterol( TC),triacylalycerol( TG),low density lipoprotein cholesterin( LDL-C) and high density lipoprotein cholesterin( HDL-C)〕,followed up 6 months for the observa-tion of cardiocerebral vascular events of the two groups were compared. Results The total effective rates of clinical and ECG of treatment group were higher than control group after treatment,the differences were statistically significant(P<0. 05). The TC,TG and LDL-C levels of treatment group were lower than control group after treatment,the differences were statistically significant(P<0. 05). Followed up 6 months,the occurrence rate of angina,myocardial infarction and heart failure of control group were higher than treatment group,the differences were statistically significant(P<0. 05). Conclusion Ginkgo biloba extract combined with atorvastatin can effectively relieve angina,decrease the level of blood lipid and reduce the incidence of ca-diocerebral vascular diseases.