CAJ | 학술논문

目的：观察自拟热哮宁汤配合常规治疗对支气管哮喘急性发作期辨证为热哮证患者血清血栓素 B2（TXB2）和6-酮基-前列腺素-1α（6-ket-PGF-1α）的影响。方法选择支气管哮喘急性发作期（辨证为热哮证）患者96例，随机分为两组，每组各48例。对照组予以支气管扩张剂联合类固醇激素为基础的常规治疗，治疗组在此基础上加用热哮宁汤口服。治疗前和治疗3 d后通过测定肺通气功能判断临床疗效，同时使用酶联免疫吸附试验法测定血清TXB2和6-ket-PGF-1α水平。结果治疗组临床总控制率显著高于对照组，差异有统计学意义（P<0.05），且较对照组更为显著地降低血清TXB2及升高血清6-ket-PGF-1α水平，差异均有统计学意义（P<0.05）。结论热哮宁汤口服配合常规治疗对支气管哮喘急性发作期辨证为热哮证患者临床疗效更好，较常规治疗更能改善TXB2和6-ket-PGF-1α等细胞因子分泌，可作为支气管哮喘急性发作期治疗的重要手段。
목적：관찰자의열효저탕배합상규치료대지기관효천급성발작기변증위열효증환자혈청혈전소 B2（TXB2）화6-동기-전렬선소-1α（6-ket-PGF-1α）적영향。방법선택지기관효천급성발작기（변증위열효증）환자96례，수궤분위량조，매조각48례。대조조여이지기관확장제연합류고순격소위기출적상규치료，치료조재차기출상가용열효저탕구복。치료전화치료3 d후통과측정폐통기공능판단림상료효，동시사용매련면역흡부시험법측정혈청TXB2화6-ket-PGF-1α수평。결과치료조림상총공제솔현저고우대조조，차이유통계학의의（P<0.05），차교대조조경위현저지강저혈청TXB2급승고혈청6-ket-PGF-1α수평，차이균유통계학의의（P<0.05）。결론열효저탕구복배합상규치료대지기관효천급성발작기변증위열효증환자림상료효경호，교상규치료경능개선TXB2화6-ket-PGF-1α등세포인자분비，가작위지기관효천급성발작기치료적중요수단。
Objective To observe the effect of self-made Rexiaoning decoction uniting conventional therapy on serum thromboxane B2 (TXB2) and 6-ket-PGF-1αof bronchial asthma patients in acute attack,i.e. heat asthma patients. Methods Randomly divided 96 selected bronchial asthma patients in acute attack (i.e. heat asthma patients) into two groups,48 in each. Gave bronchodilators and steroid hormone as basic conventional therapy to both groups ,while adding Rexiaoning decoction to treatment group. Judged the clinical therapeutic effect by determining pulmonary ventilation functions before treatment and after three days of treatment. Also used enzyme linked immunosorbent assay to determine TXB2 and 6-ket-PGF-1αlevel. Results The total control rate of treatment group was clearly higher than that of control group,difference showing statistic significance(P<0.05). Treatment group prominently reduced TXB2 and rose 6-ket-PGF-1αlevel comparing to control group,difference showing statistic significance(P<0.05). Conclusion The clinical therapeutic effect of Rexiaoning decoction uniting conventional therapy is better than just using conventional therapy on bronchial asthma patients in acute attack ,i.e. heat asthma patients. It is more likely to im-prove TXB2 and 6-ket-PGF-1αcytokines secreting and can be used as an important method to treat bronchial asthma patients in acute attack.