CAJ | 학술논문

目的：观察α-硫辛酸治疗2型糖尿病合并周围神经病变（ DPN）对视诱发电位影响。方法：将80例糖尿病性周围神经病变患者随机分为两组，各40例。对照组给予甲钴胺500μg静脉推注，1次/d；治疗组α-硫辛酸600 mg稀释后静脉滴注，1次/d，用药2周。选定视诱发电位P100波幅作为视力量化评价指标，两组治疗前后P100进行对照研究分析。结果：治疗前治疗组视诱发电位P100波振幅及潜伏期分别为（0.198±0.031）μV（、100.197±7.354）ms，对照组视诱发电位P100波振幅及潜伏期分别为（0.198±0.035）μV（、100.191±7.665）ms，两者比较差异均无统计学意义（P＞0.05）。治疗后对照组P100波振幅及潜伏期分别为（0.209±0.016）μV（、100.104±9.003）ms，治疗组P100波振幅及潜伏期分别为（0.236±0.015）μV、（97.668±6.783）ms，与治疗前相比，差异均有统计学意义（P＜0.05）；与对照相比差异均有统计学意义（P＜0.05）。结论：α-硫辛酸早期应用对糖尿病视网膜病变单纯期视诱发电位P100波潜时及振幅有影响，提示对视力、视神经传导有保护作用。
목적：관찰α-류신산치료2형당뇨병합병주위신경병변（ DPN）대시유발전위영향。방법：장80례당뇨병성주위신경병변환자수궤분위량조，각40례。대조조급여갑고알500μg정맥추주，1차/d；치료조α-류신산600 mg희석후정맥적주，1차/d，용약2주。선정시유발전위P100파폭작위시역량화평개지표，량조치료전후P100진행대조연구분석。결과：치료전치료조시유발전위P100파진폭급잠복기분별위（0.198±0.031）μV（、100.197±7.354）ms，대조조시유발전위P100파진폭급잠복기분별위（0.198±0.035）μV（、100.191±7.665）ms，량자비교차이균무통계학의의（P＞0.05）。치료후대조조P100파진폭급잠복기분별위（0.209±0.016）μV（、100.104±9.003）ms，치료조P100파진폭급잠복기분별위（0.236±0.015）μV、（97.668±6.783）ms，여치료전상비，차이균유통계학의의（P＜0.05）；여대조상비차이균유통계학의의（P＜0.05）。결론：α-류신산조기응용대당뇨병시망막병변단순기시유발전위P100파잠시급진폭유영향，제시대시력、시신경전도유보호작용。
objective To study the effect on visual evoked potential of alpha lipoic acid in the treatment of type 2 diabetic peripheral neu-ropathy. Method 80 patients of diabetic peripheral neuropathy were randomly divided into control group and trial group (n=40). The control group was treated with methylcobalamin 500μg intravenous injection,once every day. The trial group was treated with alpha lipoic acid 600 mg intravenous drip after dilution,once every day. The course of treatment was 2 weeks. The P100 amplitude of visual evoked potential was select-ed as the quantitative evaluation indicator of vision. The P100 before and after treatment in two groups were compared for statistical analy-sis. Results Before treatment,in control group the P100 amplitude and latentperiod of visual evoked potential were(0. 198 ± 0. 035)μV、(100. 191 ± 7. 665)ms respectively,in trial group the P100 amplitude and latentperiod of visual evoked potential were(0. 198 ± 0. 031)μV、(100. 197 ± 7. 354)ms respectively. There were no statistical significance(P>0. 05). After treatment,in trial group the P100 amplitude and latentperiod of visual evoked potential were(0. 236 ± 0. 015)μV(、97. 668 ± 6. 783)ms respectively,in control group the P100 amplitude and latentperiod of visual evoked potential were(0. 209 ± 0. 016)μV(、100. 104 ± 9. 003)ms respectively. There were statistical significance be-tween before treatment and after treatment(P<0. 05). There were statistical significance between control group and trial group(P<0. 05) . Conclusion The is a certain influence of alpha lipoic acid in the early treatment of simple diabetic retinopathy on the P100 amplitude and la-tentperiod of visual evoked potential. This indicates that alpha lipoic acid has a protective effect on the eyesight and optic nerve conduction.