中华胃食管反流病电子杂志
中華胃食管反流病電子雜誌
중화위식관반류병전자잡지
Chinese Journal of Gastroesphageal Reflux Disease (Electronic Edition)
2014年
1期
28-33
,共6页
睡眠呼吸暂停,阻塞性%胃食管反流%压力
睡眠呼吸暫停,阻塞性%胃食管反流%壓力
수면호흡잠정,조새성%위식관반류%압력
Sleep apnea%Obstructive%Gastroesophageal reflux disease%Pressure
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)与胃反流性疾病(gastroesophageal reflux disease)的关系。方法2013年2月至2014年6月期间就诊于新疆维吾尔自治区人民医院的 OSAHS 患者30例,采用多导睡眠监测、24 h 多通道腔阻抗-pH 监测和高分辨率胃肠动力学检查系统进行监测,观察食管上、下括约肌、食管动力学特点及反流事件相关指标,并与10例健康成人对照组比较,比较组间各测量指标差异。结果OSAHS 组较对照组食管上括约肌松弛持续时间、食管上括约肌松弛恢复时间、食管下括约肌长度、远端收缩积分平均值均减小,收缩前沿速度增加,差异均具有统计学意义(t =-2.061、-2.044、-2.525、-2.076、2.522,P 均<0.05)。OSAHS 组与对照组中 DeMeester 评分中位数(M[P25;P75])分别为11.3[5.1;37.8]、3.8[2.8;11.1]分。食管近端反流总次数分别为41.5[23.8;65.3]、24.5[16.3;27.8]次,酸反流次数分别为20.0[10.0;32.0]、10.5[7.8;14.3]次。OSAHS 组食管近端反流总次数、酸反流次数及 DeMeester 评分均较对照组增加,差异均有统计学意义(z =-2.438、-2.361、-2.140,P 均<0.05)。结论OSAHS 部分患者存在食管上、下括约肌结构和功能障碍,存在胃食管反流现象,食管近端反流以酸性物质为主。
目的:探討阻塞性睡眠呼吸暫停低通氣綜閤徵(obstructive sleep apnea hypopnea syndrome,OSAHS)與胃反流性疾病(gastroesophageal reflux disease)的關繫。方法2013年2月至2014年6月期間就診于新疆維吾爾自治區人民醫院的 OSAHS 患者30例,採用多導睡眠鑑測、24 h 多通道腔阻抗-pH 鑑測和高分辨率胃腸動力學檢查繫統進行鑑測,觀察食管上、下括約肌、食管動力學特點及反流事件相關指標,併與10例健康成人對照組比較,比較組間各測量指標差異。結果OSAHS 組較對照組食管上括約肌鬆弛持續時間、食管上括約肌鬆弛恢複時間、食管下括約肌長度、遠耑收縮積分平均值均減小,收縮前沿速度增加,差異均具有統計學意義(t =-2.061、-2.044、-2.525、-2.076、2.522,P 均<0.05)。OSAHS 組與對照組中 DeMeester 評分中位數(M[P25;P75])分彆為11.3[5.1;37.8]、3.8[2.8;11.1]分。食管近耑反流總次數分彆為41.5[23.8;65.3]、24.5[16.3;27.8]次,痠反流次數分彆為20.0[10.0;32.0]、10.5[7.8;14.3]次。OSAHS 組食管近耑反流總次數、痠反流次數及 DeMeester 評分均較對照組增加,差異均有統計學意義(z =-2.438、-2.361、-2.140,P 均<0.05)。結論OSAHS 部分患者存在食管上、下括約肌結構和功能障礙,存在胃食管反流現象,食管近耑反流以痠性物質為主。
목적:탐토조새성수면호흡잠정저통기종합정(obstructive sleep apnea hypopnea syndrome,OSAHS)여위반류성질병(gastroesophageal reflux disease)적관계。방법2013년2월지2014년6월기간취진우신강유오이자치구인민의원적 OSAHS 환자30례,채용다도수면감측、24 h 다통도강조항-pH 감측화고분변솔위장동역학검사계통진행감측,관찰식관상、하괄약기、식관동역학특점급반류사건상관지표,병여10례건강성인대조조비교,비교조간각측량지표차이。결과OSAHS 조교대조조식관상괄약기송이지속시간、식관상괄약기송이회복시간、식관하괄약기장도、원단수축적분평균치균감소,수축전연속도증가,차이균구유통계학의의(t =-2.061、-2.044、-2.525、-2.076、2.522,P 균<0.05)。OSAHS 조여대조조중 DeMeester 평분중위수(M[P25;P75])분별위11.3[5.1;37.8]、3.8[2.8;11.1]분。식관근단반류총차수분별위41.5[23.8;65.3]、24.5[16.3;27.8]차,산반류차수분별위20.0[10.0;32.0]、10.5[7.8;14.3]차。OSAHS 조식관근단반류총차수、산반류차수급 DeMeester 평분균교대조조증가,차이균유통계학의의(z =-2.438、-2.361、-2.140,P 균<0.05)。결론OSAHS 부분환자존재식관상、하괄약기결구화공능장애,존재위식관반류현상,식관근단반류이산성물질위주。
Objective Through monitoring esophageal dynamic change, detection of laryngopharyngeal reflux and gastroesophageal reflux events,to discuss the relationship of OSAHS with laryngopharyngeal reflux.Methods Thirty patients with OSAHS were diagnosed by polysomnography in the Xinjiang autonomous region people′s hospital between February 2013 and June 2014.This study applied high-resolution esophageal manometry and ambulatory 24-hour multichannel intraluminal impedance-pH monitoring to obtain the upper esophageal sphincter pressure and lower esophageal sphincter pressure, characteristics of sectional esophageal motility;laryngopharyngeal reflux and gastroesophageal reflux events, as well as the reflux properties of substance.Ten healthy persons were recruited as normal controls.Results UES relaxation duration,duration of UES relaxtion time,UES relaxtion recovery time and mean length of LES were all shorter than those of the control group (t were -2.061, -2.044,-2.525,-2.076 and 2.522,P <0.05).Median scores of Demeester were11.3[5.1;37.8]and 3.8[2.8;11.1]in OSAHS group and the controls,median frequency of total reflux episodes were 41.5[23.8;65.3]and 24.5[16.3;27.8].The frequency of total reflux episodes,time of acid clearance,Demeester scores were increased or higher in OSAHS group than those in the controls(z were -2.438, -2.361 and -2.140,P <0.05). Conclusion There are upper esophageal sphincter and lower esophageal sphincter dismotility in OSAHS patients.Esophageal dynamic disfunction should be considered in the study of the pathogenesis of OSAHS.