CAJ | 학술논문

目的：：探讨血浆脂蛋白a[ Lp( a)]、高敏C反应蛋白( hs-CRP)、脑钠肽( BNP)水平与冠状动脉病变程度的相关性。方法：将216例行冠状动脉造影患者根据造影结果分为冠心病组129例(包括单支病变组35例、双支病变组40例和三支病变组54例)和对照组87例。分别检测各组患者血浆Lp( a)、hs-CRP、BNP水平，并分析其与冠状动脉病变支数及Gensini评分的相关性。结果：冠心病组患者血浆Lp(a)、hs-CRP和BNP水平均明显高于对照组(P<0.01)。不同病变支数各组血浆Lp(a)、hs-CRP、BNP水平差异均有统计学意义，其中三支病变组均明显高于对照组及单支病变组(P<0.01)。随着Gensini评分升高，血浆Lp(a)、hs-CRP和BNP水平也随之升高(P<0.01)。冠心病组血浆Lp(a)、hs-CRP和BNP水平与冠状动脉病变支数及冠状动脉Gensini评分均呈正相关关系(P<0.01)。结论：联合检测血浆Lp(a)、hs-CRP、BNP水平对判断冠状动脉病变程度具有指导意义。
목적：：탐토혈장지단백a[ Lp( a)]、고민C반응단백( hs-CRP)、뇌납태( BNP)수평여관상동맥병변정도적상관성。방법：장216례행관상동맥조영환자근거조영결과분위관심병조129례(포괄단지병변조35례、쌍지병변조40례화삼지병변조54례)화대조조87례。분별검측각조환자혈장Lp( a)、hs-CRP、BNP수평，병분석기여관상동맥병변지수급Gensini평분적상관성。결과：관심병조환자혈장Lp(a)、hs-CRP화BNP수평균명현고우대조조(P<0.01)。불동병변지수각조혈장Lp(a)、hs-CRP、BNP수평차이균유통계학의의，기중삼지병변조균명현고우대조조급단지병변조(P<0.01)。수착Gensini평분승고，혈장Lp(a)、hs-CRP화BNP수평야수지승고(P<0.01)。관심병조혈장Lp(a)、hs-CRP화BNP수평여관상동맥병변지수급관상동맥Gensini평분균정정상관관계(P<0.01)。결론：연합검측혈장Lp(a)、hs-CRP、BNP수평대판단관상동맥병변정도구유지도의의。
Objective:To explore the correlation between the levels of the plasma lipoprotein( a) [ Lp( a) ] ,high sensitive C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) with the severity of coronary artery disease(CAD). Methods:According to the results of coronary angiography,216 patients were divided into the CAD group(216 cases) and control group(87 cases),and the CAD group were subdivided into the single-vessel disease group(35 cases),double-vessel disease group(40 cases) and three-vessel disease group(54 cases). The levels of the plasma Lp(a),hs-CRP and BNP in all groups were detected,and the correlations of whose with coronary lesion vessels and Gensini scores were analyzed. Results:The levels of Lp ( a ) , hs-CRP and BNP in CAD group were significantly higher than those in control group(P<0. 01). The differences of the levels of Lp(a),hs-CRP and BNP in different vessels disease group were statistically significant(P<0. 01),and the levels of Lp(a),hs-CRP and BNP in three-vessel disease group were significantly higher than those in control group and single-vessel disease group(P<0. 01). With the increasing of Gensini score,the levels of plasma Lp(a),hs-CRP and BNP increased(P<0. 01). There was a positive correlation between the levels of Lp(a),hs-CRP and BNP with coronary lesion vessels and Gensini scores(P<0. 01). Conclusions:The combined detection of the levels of plasma Lp ( a) ,hs-CRP and BNP has an important significance in judging the severity of coronary artery disease.