CAJ | 학술논문

目的：：探讨CD4+ CD25+调节性T细胞在晚期肺癌中的表达及其临床意义。方法：应用流式细胞术分析42例肺癌患者(肺癌组)外周血CD4+ CD25+调节性T细胞表达水平，与15名健康志愿者作对照。结果：肺癌组患者外周血CD4+ CD25+调节性T细胞数量为(7.17±3.63)%，明显高于对照组的(4.25±2.11)%(P<0.01)。肺癌组患者外周血中调节性T细胞数量在病理类型间差异无统计学意义(P>0.05)，晚期肺癌患者外周调节性T细胞数量高于早期患者(P<0.05)。结论：调节性T细胞在肺癌患者中比率明显升高，并与临床进展有关。
목적：：탐토CD4+ CD25+조절성T세포재만기폐암중적표체급기림상의의。방법：응용류식세포술분석42례폐암환자(폐암조)외주혈CD4+ CD25+조절성T세포표체수평，여15명건강지원자작대조。결과：폐암조환자외주혈CD4+ CD25+조절성T세포수량위(7.17±3.63)%，명현고우대조조적(4.25±2.11)%(P<0.01)。폐암조환자외주혈중조절성T세포수량재병리류형간차이무통계학의의(P>0.05)，만기폐암환자외주조절성T세포수량고우조기환자(P<0.05)。결론：조절성T세포재폐암환자중비솔명현승고，병여림상진전유관。
Objective:To explore the expression and clinical significance of CD4 + CD25 + regulatory T cells in patients with lung cancer. Methods:The expression of CD4 + CD25 + regulatory T cells in the peripheral blood of 42 patients with lung cancer( lung cancer group) and 15 healthy volunteers was determined by flow cytometry. Results:The number of CD4 + CD25 + regulatory T cells in the lung cancergroup(7.17±3.63)%wassignificantlyhigherthanthatinthehealthycontrols(4.25±2.11)%(P <0.01).Thelevelof CD4 + CD25 + regulatory T cells in the lung cancer patients with different pathological classifications had no statistically significant difference(P>0. 05). The level of CD4 + CD25 + regulatory T cells in patients with advanced lung cancer was significantly higher than that in patients with early lung cancer(P<0. 05). Conclusions:The proportion of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with lung cancer is significantly increased,which is related to the progression of lung cancer.