CAJ | 학술논문

结直肠息肉尤其是腺瘤性息肉被认为是结直肠癌的癌前病变，其发生与生活方式、饮食习惯、遗传因素等有关。目的：探讨内蒙古地区生活、饮食因素对结直肠息肉发生的影响。方法：采用以结肠镜检查为基础的病例对照研究。选择2012-2013年在包头医学院第二附属医院检出结直肠息肉者100例作为病例组，同期200例性别、年龄、民族匹配且未检出息肉者作为对照组，进行包括人口统计学资料、生活方式、饮食习惯等内容的问卷调查，对可能与结直肠息肉有关的变量行单因素分析，有统计学意义者进一步行多因素条件Logistic 回归分析。结果： Logistic 回归分析显示，经调整年龄、性别、民族、婚姻状况、文化程度等因素，生活因素中，吸烟（OR =1.3，95% CI：1.0~1.8）、饮酒（OR =1.5，95% CI：1.1~2.0）为结直肠息肉的危险因素，体育锻炼≥4次/周为保护因素（ OR =0.6，95% CI：0.4~0.8）；饮食因素中，常食细粮（ OR =1.7，95% CI：1.2~2.8）、喜食肥肉（ OR =1.4，95% CI：1.2~1.9）、常食盐浸/腌制（OR =1.4，95% CI：1.1~1.8）、烧烤/油炸食品（OR =1.6，95% CI：1.1~2.3）为危险因素，常食蔬菜（OR =0.6，95% CI：0.4~0.9）、水果（OR =0.5，95% CI：0.4~0.7）为保护因素。结论：内蒙古地区结直肠息肉的发生与不良生活、饮食习惯有关，戒除烟酒、加强体育锻炼、常食蔬菜、水果、少食动物脂肪和加工食品可能降低结直肠息肉的发生风险。
결직장식육우기시선류성식육피인위시결직장암적암전병변，기발생여생활방식、음식습관、유전인소등유관。목적：탐토내몽고지구생활、음식인소대결직장식육발생적영향。방법：채용이결장경검사위기출적병례대조연구。선택2012-2013년재포두의학원제이부속의원검출결직장식육자100례작위병례조，동기200례성별、년령、민족필배차미검출식육자작위대조조，진행포괄인구통계학자료、생활방식、음식습관등내용적문권조사，대가능여결직장식육유관적변량행단인소분석，유통계학의의자진일보행다인소조건Logistic 회귀분석。결과： Logistic 회귀분석현시，경조정년령、성별、민족、혼인상황、문화정도등인소，생활인소중，흡연（OR =1.3，95% CI：1.0~1.8）、음주（OR =1.5，95% CI：1.1~2.0）위결직장식육적위험인소，체육단련≥4차/주위보호인소（ OR =0.6，95% CI：0.4~0.8）；음식인소중，상식세량（ OR =1.7，95% CI：1.2~2.8）、희식비육（ OR =1.4，95% CI：1.2~1.9）、상식염침/업제（OR =1.4，95% CI：1.1~1.8）、소고/유작식품（OR =1.6，95% CI：1.1~2.3）위위험인소，상식소채（OR =0.6，95% CI：0.4~0.9）、수과（OR =0.5，95% CI：0.4~0.7）위보호인소。결론：내몽고지구결직장식육적발생여불량생활、음식습관유관，계제연주、가강체육단련、상식소채、수과、소식동물지방화가공식품가능강저결직장식육적발생풍험。
Background:Colorectal polyp,especially adenomatous polyp is considered to be a precancerous lesion of colorectal cancer;its occurrence is associated with lifestyle,food habits and genetic factors. Aims:To explore the impact of lifestyle and dietary factors on occurrence of colorectal polyps in Inner Mongolia area. Methods:A colonoscopy-based case-control study was performed. In 2012-2013,100 cases of colorectal polyps and 200 sex-,age-and nationality-matched polyp-free cases were recruited at the Second Affiliated Hospital of Baotou Medical College and were asked to complete a questionnaire including information on demography,lifestyle,and food habits,etc. Multivariate conditional Logistic regression analysis was used to estimate the possible colorectal polyp-related factors which were statistically significant in univariate analysis. Results:In lifestyle factors,after adjusted for age,sex,nationality,marital status and educational level,cigarette smoking (OR=1. 3,95% CI:1. 0-1. 8)and alcohol drinking(OR=1. 5,95% CI:1. 1-2. 0)were identified as the risk factors for colorectal polyps by Logistic regression analysis,while physical activity at least 4 times per week was a protective factor (OR=0. 6,95% CI:0. 4-0. 8). In dietary factors,wheat flour and rice(OR=1. 7,95% CI:1. 2-2. 8),fatty meat (OR=1. 4,95% CI:1. 2-1. 9),salt/pickled food(OR=1. 4,95% CI:1. 1-1. 8)and barbecue/fried food(OR=1. 6, 95% CI:1. 1-2. 3)were identified as the risk factors,while vegetables(OR=0. 6,95% CI:0. 4-0. 9)and fruits(OR=0. 5,95% CI:0. 4-0. 7)were protective factors after adjustment. Conclusions:Occurrence of colorectal polyps in Inner Mongolia area is associated with unhealthy lifestyle and food habits. Cessation of cigarette smoking and alcohol drinking, more physical activity,frequent consumption of vegetables and fruits,and less animal fat and processed food might decrease the risk of colorectal polyps.