CAJ | 학술논문

慢性阻塞性肺疾病（COPD）患者常伴有胃肠动力障碍，而四磨汤具有促进胃肠动力的作用。目的：探讨四磨汤对COPD 患者胃肠道症状和胃肠动力的影响。方法：收集2012年9月至2013年6月十堰市人民医院稳定期COPD 患者36例，予四磨汤口服液28 d，19名健康体检者作为对照组。所有入组者行胃肠道症状等级量表（GSRS）评分、胃电图检查和外周血血管活性肠肽（ VIP）、肠脂肪酸结合蛋白（ I-FABP）水平测定。COPD 组疗程结束后重复上述检查。结果：COPD 组治疗前GSRS 评分、血清I-FABP 水平高于对照组，血清VIP 水平和空腹、餐后正常胃慢波百分率（N%）低于对照组，差异均有统计学意义（ P <0.05）；经28 d 四磨汤治疗后，COPD 组上述指标与治疗前相比均有明显改善（P <0.05），其中血清VIP、I-FABP 水平和N%已接近正常水平。结论：四磨汤可改善COPD 患者的胃肠道症状和胃肠动力，其对胃肠动力的调节作用可能呈双向性。
만성조새성폐질병（COPD）환자상반유위장동력장애，이사마탕구유촉진위장동력적작용。목적：탐토사마탕대COPD 환자위장도증상화위장동력적영향。방법：수집2012년9월지2013년6월십언시인민의원은정기COPD 환자36례，여사마탕구복액28 d，19명건강체검자작위대조조。소유입조자행위장도증상등급량표（GSRS）평분、위전도검사화외주혈혈관활성장태（ VIP）、장지방산결합단백（ I-FABP）수평측정。COPD 조료정결속후중복상술검사。결과：COPD 조치료전GSRS 평분、혈청I-FABP 수평고우대조조，혈청VIP 수평화공복、찬후정상위만파백분솔（N%）저우대조조，차이균유통계학의의（ P <0.05）；경28 d 사마탕치료후，COPD 조상술지표여치료전상비균유명현개선（P <0.05），기중혈청VIP、I-FABP 수평화N%이접근정상수평。결론：사마탕가개선COPD 환자적위장도증상화위장동력，기대위장동력적조절작용가능정쌍향성。
Background:Gastrointestinal dysmotility is frequently seen in patients with chronic obstructive pulmonary disease ( COPD). Simo Decoction is used for promoting gastrointestinal motility in clinical practice. Aims:To study the effect of Simo Decoction on gastrointestinal symptoms and motility in patients with COPD. Methods:Thirty-six patients with stable COPD in Shiyan Renmin Hospital from Sep. 2012 to Jun. 2013 were enrolled and received a 28-day course treatment of Simo Decoction oral solution,19 healthy volunteers were served as controls. All subjects were assessed with gastrointestinal symptom rating scale(GSRS). Electrogastrography was performed and levels of vasoactive intestinal peptide(VIP)and intestinal fatty acid-binding protein( I-FABP)in peripheral blood were measured. Patients with COPD were re-examined for the above-mentioned parameters after treated with Simo Decoction. Results:The baseline GSRS score and serum I-FABP level in COPD patients were significantly increased as compared with controls(P<0. 05),while the baseline serum VIP level,as well as the fasting and postprandial normal gastric slow wave percentage in COPD patients were significantly decreased(P <0. 05). After 28-day course of Simo Decoction treatment,all these parameters in COPD patients were improved as compared with those before treatment(P<0. 05),serum levels of VIP,I-FABP and normal gastric slow wave percentage were similar to those of controls. Conclusions:Simo Decoction can ameliorate the gastrointestinal symptoms and dysmotility in patients with COPD. The regulatory effect of Simo Decoction on gastrointestinal motility might be bidirectional.