CAJ | 학술논문

功能性消化不良（ FD）的病因和发病机制尚不明了，近年研究表明免疫反应在食物过敏、炎症相关和感染后FD的发病中起介导作用，十二指肠黏膜嗜酸细胞增多和激活、胃和十二指肠局部炎症免疫细胞浸润、外周免疫反应与胃排空延迟、近端胃感觉功能下降、内脏高敏感和FD症状相关。从阻断免疫反应的角度探讨难治性或特殊类型FD的治疗具有一定的前景。
공능성소화불량（ FD）적병인화발병궤제상불명료，근년연구표명면역반응재식물과민、염증상관화감염후FD적발병중기개도작용，십이지장점막기산세포증다화격활、위화십이지장국부염증면역세포침윤、외주면역반응여위배공연지、근단위감각공능하강、내장고민감화FD증상상관。종조단면역반응적각도탐토난치성혹특수류형FD적치료구유일정적전경。
The etiology and pathogenesis of functional dyspepsia( FD)are still unknown,recent studies showed that immune responses play a mediation role in the pathogenesis of food allergy,inflammation-related and post-infectious FD. The increased and activated eosinophils in duodenal mucosa,the infiltration of inflammatory immune cells in gastric and duodenal mucosa,and the peripheral immune responses are correlated with delayed gastric emptying,decrease of sensory function of proximal stomach,visceral hypersensitivity and FD symptoms. Strategies that suppress immune response might be prospective for subset of FD patients with evidences of immune dysregulation.