CAJ | 학술논문

目的：了解高原红细胞增多症（HAPC）患者凝血功能的损伤状况。方法选择高HAPC患者69例，检测空腹血浆标本活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（Fbg）水平。以生活在同海拔地的健康人群作为高原对照组进行比较分析。结果HAPC患者Fbg、APTT、TT水平均高于高原对照组（P＜0．05），PT水平比较差异无统计学意义（P＞0．05）；动态观察表明，综合治疗可促进HAPC患者凝血功能恢复正常。结论HAPC患者出血与凝血两个过程十分复杂，既包含生理性的适应过程，同时也包含着从生理适应到病理改变的演变过程。
목적：료해고원홍세포증다증（HAPC）환자응혈공능적손상상황。방법선택고HAPC환자69례，검측공복혈장표본활화부분응혈활매시간（APTT）、응혈매원시간（PT）、응혈매시간（TT）、섬유단백원（Fbg）수평。이생활재동해발지적건강인군작위고원대조조진행비교분석。결과HAPC환자Fbg、APTT、TT수평균고우고원대조조（P＜0．05），PT수평비교차이무통계학의의（P＞0．05）；동태관찰표명，종합치료가촉진HAPC환자응혈공능회복정상。결론HAPC환자출혈여응혈량개과정십분복잡，기포함생이성적괄응과정，동시야포함착종생리괄응도병리개변적연변과정。
Objective To investigate changes of coagulation function in patients with high altitude polycythemia (HAPC) .Meth‐ods Activated partial thromboplastin time (APTT) ,prothrombin time (PT) ,thrombin time (TT) and fibrinogen (Fbg) were de‐tected and compared between 69 patients with HAPC and 60 healthy subjects (controls) .Results Fbg ,APTT and TT levels in pa‐tients with HAPC were higher than controls (P<0 .05) ,while the difference of PT was not significant (P>0 .05) .Dynamic obser‐vation indicated that comprehensive therapy could these recover coagulation function .Conclusion Hemorrhage and coagulation process in patients with HAPC could be very complicated ,including physiological adaptation and the process of physiology evolving into pathology .