黑龙江科学
黑龍江科學
흑룡강과학
Helongjiang Science
2015年
5期
6-7
,共2页
王怡军%曲艺%张所宏%王丽娟%孙秀琪
王怡軍%麯藝%張所宏%王麗娟%孫秀琪
왕이군%곡예%장소굉%왕려연%손수기
慢性阻塞性肺疾病%8-羟基脱氧鸟苷酸%锰超氧化物歧化酶%BODE指数
慢性阻塞性肺疾病%8-羥基脫氧鳥苷痠%錳超氧化物歧化酶%BODE指數
만성조새성폐질병%8-간기탈양조감산%맹초양화물기화매%BODE지수
Chronic obstructive pulmonary disease%8-hydroxy-2'-deoxyguanosine%Manganese superoxide dismutase%BODE indexes
通过探讨慢性阻塞性肺疾病急性加重期(AECOPD)血清8-羟基脱氧鸟苷酸(8-OHdG)和锰超氧化物歧化酶(MnSOD )水平的特点,相关分析其与BODE指数的关系。选择AECOPD患者96例,健康对照组90例,检测血清8-OHdG水平及MnSOD水平,与AECOPD患者BODE指数进行相关分析。结果发现:与健康对照组比较,AECOPD患者血清8-OHdG升高、MnSOD降低,差异有显著性(p<0.05)。AECOPD患者血清8-OHdG与MnSOD呈负相关(p<0.01);血清8-OHdG与BODE指数正相关(p<0.01),血清MnSOD与BODE指数负相关(p<0.01)。说明8-OHdG与MnSOD水平的变化与AECOPD的病情严重程度相关。
通過探討慢性阻塞性肺疾病急性加重期(AECOPD)血清8-羥基脫氧鳥苷痠(8-OHdG)和錳超氧化物歧化酶(MnSOD )水平的特點,相關分析其與BODE指數的關繫。選擇AECOPD患者96例,健康對照組90例,檢測血清8-OHdG水平及MnSOD水平,與AECOPD患者BODE指數進行相關分析。結果髮現:與健康對照組比較,AECOPD患者血清8-OHdG升高、MnSOD降低,差異有顯著性(p<0.05)。AECOPD患者血清8-OHdG與MnSOD呈負相關(p<0.01);血清8-OHdG與BODE指數正相關(p<0.01),血清MnSOD與BODE指數負相關(p<0.01)。說明8-OHdG與MnSOD水平的變化與AECOPD的病情嚴重程度相關。
통과탐토만성조새성폐질병급성가중기(AECOPD)혈청8-간기탈양조감산(8-OHdG)화맹초양화물기화매(MnSOD )수평적특점,상관분석기여BODE지수적관계。선택AECOPD환자96례,건강대조조90례,검측혈청8-OHdG수평급MnSOD수평,여AECOPD환자BODE지수진행상관분석。결과발현:여건강대조조비교,AECOPD환자혈청8-OHdG승고、MnSOD강저,차이유현저성(p<0.05)。AECOPD환자혈청8-OHdG여MnSOD정부상관(p<0.01);혈청8-OHdG여BODE지수정상관(p<0.01),혈청MnSOD여BODE지수부상관(p<0.01)。설명8-OHdG여MnSOD수평적변화여AECOPD적병정엄중정도상관。
To analyze the relationship of serum 8-OHdG,MnSOD levels and BODE indexes in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD),and investigate the clinical value of serum 8-OHdG and MnSOD in evaluating disease severity and prognosis. A comparative study was performed in 96 AECOPD patients and 90 matched healthy individuals. The serum levels of 8-OHdG and MnSOD in both groups were measured.Correlation analysis was performed between serum 8-OHdG,MnSOD levels and BODE indexes in the patients with AECOPD. The serum 8-OHdG concentrations were higher, serum MnSOD concentrations were lower in patients with AECOPD compared with those in control subjects. There were statistical significances (p<0. 01). MnSOD levels were correlated negatively with 8-OHdG levels in patients with AECOPD (p<0.01). 8-OHdG levels were correlated positively with BODE indexes. MnSOD levels were correlated negatively with BODE indexes. Detection of serum 8-OHdG and MnSOD can help evaluate the severity of COPD.