CAJ | 학술논문

目的：通过检测早期梅毒患者外周血T淋巴细胞亚群，了解机体在梅毒早期感染时的细胞免疫状况，以指导临床治疗。方法应用流式细胞仪检测59名志愿者外周血CD3＋、CD4＋、CD8＋淋巴细胞亚群，其中健康对照组20例，一期梅毒（PS ）组10例，二期梅毒（SS）组15例，早期潜伏梅毒（ELS）组14例。结果早期梅毒各组CD3＋、CD4＋、CD8＋均高于对照组，CD3＋是SS组最高，PS组次之，ELS组第3，组间差异有统计学意义（P＜0．05），SS组高于对照组且差异有统计学意义（P＜0．05）。CD4＋为ELS组最高，SS组次之，PS组第3，组间差异有统计学意义（P＜0．05）。CD8＋为PS组最高，SS组次之，ELS组第3，组间差异无统计学意义（ P＞0．05），CD4＋／CD8＋差异无统计学意义（ P＞0．05）。结论早期梅毒细胞免疫有增强，这对清除 T P是非常有利的。
목적：통과검측조기매독환자외주혈T림파세포아군，료해궤체재매독조기감염시적세포면역상황，이지도림상치료。방법응용류식세포의검측59명지원자외주혈CD3＋、CD4＋、CD8＋림파세포아군，기중건강대조조20례，일기매독（PS ）조10례，이기매독（SS）조15례，조기잠복매독（ELS）조14례。결과조기매독각조CD3＋、CD4＋、CD8＋균고우대조조，CD3＋시SS조최고，PS조차지，ELS조제3，조간차이유통계학의의（P＜0．05），SS조고우대조조차차이유통계학의의（P＜0．05）。CD4＋위ELS조최고，SS조차지，PS조제3，조간차이유통계학의의（P＜0．05）。CD8＋위PS조최고，SS조차지，ELS조제3，조간차이무통계학의의（ P＞0．05），CD4＋／CD8＋차이무통계학의의（ P＞0．05）。결론조기매독세포면역유증강，저대청제 T P시비상유리적。
Objective To detect the lymphocyte subpopulations in patients with early syphilis ,so as to know their immunity con‐dition and guide clinical treatment .Methods Flow cytometry was used to detect CD3+ ,CD4+ and CD8+ lymphocyte subpopula‐tions in peripheral blood from 59 volunteers ,including 20 normal individuals (Cont group) ,10 patients with primary syphilis (PS group) ,15 patients with secondary syphilis (SS group) and 14 patients with early latent syphilis (ELS group) .Results CD3+ , CD4+ and CD8+ lymphocyte subpopulations in each syphilis groups were higher than Cont group .SS group had the highest CD3+level ,second was PS group ,and third was ELS group .There was significant difference among three groups (P<0 .05) .The CD3+level of SS group was significantly higher than that of Cont group (P<0 .05) .ELS group had the highest CD4+ level ,second was SS group ,third was PS group .The difference of CD4+ level was significant among three groups (P<0 .05) .PS group had the high‐est CD8+ level ,second was SS group ,third was ELS group .However ,the difference of CD8+ level among three groups was not sig‐nificant (P>0 .05) .There was no significant difference of CD4+ /CD8+ among three groups(P>0 .05) .Conclusion Cytoimmunity in early syphilis enhances ,which could be benefit to eliminate Treponema Pallidum .