CAJ | 학술논문

目的：探讨血清肌酸激酶同工酶（CK‐MB）、心肌肌钙蛋白I（cTnI）对手足口病（HFMD）患儿心肌损伤的诊断价值。方法选择2012年7月至2013年6月住院治疗的H FM D患儿80例（H FM D组），同期体检健康儿童50例（对照组）。比较两组血清CK‐MB、cTnI水平。结果 HFMD组治疗前CK‐MB、cTnI水平分别为（38．10±19．50）U／L、（0．08±0．02）μg／L ，均高于对照组（P＜0．05）。HFMD患儿治疗前CK‐MB、cTnI阳性率分别为56．3％、33．8％，阳性率比较差异有统计学意义（P＜0．05）。经治疗后，HFMD患儿CK‐MB、cTnI水平均明显下降（P＜0．05）。结论联合检测血清CK‐MB、cTnI对 HFMD合并心肌损伤的早期诊断具有重要临床意义。
목적：탐토혈청기산격매동공매（CK‐MB）、심기기개단백I（cTnI）대수족구병（HFMD）환인심기손상적진단개치。방법선택2012년7월지2013년6월주원치료적H FM D환인80례（H FM D조），동기체검건강인동50례（대조조）。비교량조혈청CK‐MB、cTnI수평。결과 HFMD조치료전CK‐MB、cTnI수평분별위（38．10±19．50）U／L、（0．08±0．02）μg／L ，균고우대조조（P＜0．05）。HFMD환인치료전CK‐MB、cTnI양성솔분별위56．3％、33．8％，양성솔비교차이유통계학의의（P＜0．05）。경치료후，HFMD환인CK‐MB、cTnI수평균명현하강（P＜0．05）。결론연합검측혈청CK‐MB、cTnI대 HFMD합병심기손상적조기진단구유중요림상의의。
Objective To explore the diagnostic value of serum creatine kinase isoenzyme MB (CM‐MB) and cardiac troponin I (cTnI) for myocardial injury in children with hand‐foot‐mouth disease (HFMD) .Methods A total of 80 children with HFMD (HFMD group) and 50 healthy children (control group) were enrolled from July 2012 to June 2013 .Serum levels of CK‐MB and cTnI were compared between the two groups .Results Serum levels of CK‐MB and cTnI were (38 .10 ± 19 .50)U/L and (0 .08 ± 0 .02)μg/L in HFMD group ,which were higher than control group (P<0 .05) .In HFMD group ,the positive rate of CK‐MB was 56 .3% ,higher than the 33 .8% of cTnI (P< 0 .05) .After therapy ,serum levels of CK‐MB and cTnI were both significantly de‐creased (P<0 .05) .Conclusion Combined detection of serum CK‐MB and cTnI might be with important significance for the early diagnosis of myocardial injury in children with HFMD .