CAJ | 학술논문

目的：比较3种肾小球滤过率（GFR）估算方程估算的GFR（eGFR）对人群肾功能评估的结果差异。方法本研究回顾性分析了门诊和住院患者中同时进行血清肌酐和胱抑素C检测者，共65856例，以3个估算方程分别计算eG FR ，并比较整体及不同肾功能分组人群eGFR结果的差异。以3个方程得到的eGFR对个体肾功能重新分期，比较肾功能各分期例数分布的差异。结果与肌酐方程估算eGFR比较，另两个方程估算eGFR的相关系数分别为0．81、0．90（均 P＜0．05）。一致性分析GFR均值差值分别为6．19、1．79 mL／（min ×1．73 m2），差异有统计学意义（P＜0．01），应用肌酐方程估算eGFR时，明显高估了个体的肾功能分期。结论3种方程估算G FR有相关性但存在明显差异，在评估不同人群肾功能时应选择合适的估算方程。
목적：비교3충신소구려과솔（GFR）고산방정고산적GFR（eGFR）대인군신공능평고적결과차이。방법본연구회고성분석료문진화주원환자중동시진행혈청기항화광억소C검측자，공65856례，이3개고산방정분별계산eG FR ，병비교정체급불동신공능분조인군eGFR결과적차이。이3개방정득도적eGFR대개체신공능중신분기，비교신공능각분기례수분포적차이。결과여기항방정고산eGFR비교，령량개방정고산eGFR적상관계수분별위0．81、0．90（균 P＜0．05）。일치성분석GFR균치차치분별위6．19、1．79 mL／（min ×1．73 m2），차이유통계학의의（P＜0．01），응용기항방정고산eGFR시，명현고고료개체적신공능분기。결론3충방정고산G FR유상관성단존재명현차이，재평고불동인군신공능시응선택합괄적고산방정。
Objective To compare the difference of kidney function evaluated by using 3 different estimated glomerular filtration rate(GFR) equations in populations .Methods Retrospectively analyzed 65 856 patients who measured serum creatinine and Cysta‐tin C at the same time ,and come from the outpatients or inpatients of the hospital .The estimated GFR (eGFR) were calculated through 3 equations ,then compared the eGFR in the population and among different groups according to different kidney functions , and then grouped the people enrolled in the study again according to the eGFR calculated by using the 3 different equations and compared the differences among groups .Results Compared with the eGFR calculated by using Creatinine equation ,the correlation coefficients of the eGFRs calculated by using the other two equations were 0 .81 and 0 .90 ,respectively ,both P<0 .05 ;The differ‐ence between the means of eGFR were 6 .19 and 1 .79 mL/(min × 1 .73 m2 ) respectively with obvious significance (P<0 .01) ,in consistency analysis .There were obvious overestimation of kidney function when using Creatinine equation to calculate eGFR .Con‐clusion There is consistence and obvious difference by using the 3 CKD‐EPI′s eGFR equations .Physicians should choose suitable equations to evaluate kidney function in different populations .