CAJ | 학술논문

目的：探讨乳腺癌患者的血清瘦素（LEP）、可溶性瘦素受体（sOB‐R）的表达及两者联合游离瘦素指数（FLI）与患者临床病理特征的相关性分析。方法收集70例经病理确诊的初诊乳腺癌患者（乳腺癌组）、良性乳腺病患者（良性乳腺疾病组， n＝50）及体检健康者（健康对照组，n＝50）的血清，检测其血清LEP及sOB‐R的表达，并经体质量指数（BMI）校正后分析以上两个指标。将乳腺癌组的试验数据与其临床病理资料进行相关性分析。结果乳腺癌患者LEP水平明显高于健康对照组及良性乳腺疾病组（P＜0．05），而sOB‐R明显降低（P＜0．05）。经校正，LEP的表达仍存在组间差异（P＜0．05）；而sOB‐R的组间差异消失（P＞0．05）。乳腺癌组绝经后患者的LEP表达、FLI均与患者的pTNM分期及是否发生淋巴结转移相关（P＜0．05），且绝经后发生转移、Ⅲ、Ⅳ期患者的LEP水平分别高于无转移及0～Ⅱ期患者（P＜0．05）。结论检测乳腺癌患者的血清LEP及FLI可能是潜在的评估临床病理的指标，LEP可能促进了绝经期后乳腺癌患者的疾病进程。
목적：탐토유선암환자적혈청수소（LEP）、가용성수소수체（sOB‐R）적표체급량자연합유리수소지수（FLI）여환자림상병리특정적상관성분석。방법수집70례경병리학진적초진유선암환자（유선암조）、량성유선병환자（량성유선질병조， n＝50）급체검건강자（건강대조조，n＝50）적혈청，검측기혈청LEP급sOB‐R적표체，병경체질량지수（BMI）교정후분석이상량개지표。장유선암조적시험수거여기림상병리자료진행상관성분석。결과유선암환자LEP수평명현고우건강대조조급량성유선질병조（P＜0．05），이sOB‐R명현강저（P＜0．05）。경교정，LEP적표체잉존재조간차이（P＜0．05）；이sOB‐R적조간차이소실（P＞0．05）。유선암조절경후환자적LEP표체、FLI균여환자적pTNM분기급시부발생림파결전이상관（P＜0．05），차절경후발생전이、Ⅲ、Ⅳ기환자적LEP수평분별고우무전이급0～Ⅱ기환자（P＜0．05）。결론검측유선암환자적혈청LEP급FLI가능시잠재적평고림상병리적지표，LEP가능촉진료절경기후유선암환자적질병진정。
Objective To explore the levels of leptin(LEP) and soluble leptin receptor (sOB‐R) in breast cancer patients′ser‐um ,and to discuss the relationship between LEP ,sOB‐R ,free leptin index(FLI) and the patients′clinical pathologic features .Meth‐ods 70 serum specimens of breast cancer patients who confirmed by pathological diagnosis were collected before the surgery ,the serum of benign breast disease group(n=50) and normal group(n=50) were also collected as control .The levels of LEP and sOB‐Rinserumweredetected,andtheresultafterbodymassindex(BMI)correctionwereanalyzed.Finally,therelationshipbetweenthe expression of LEP ,sOB‐R and clinical pathologic features were analyzed .Results The serum level of LEP in breast cancer group was highly increased than the other two groups (P<0 .05) ,and sOB‐R was reduced(P<0 .05) .After BMI correction ,LEP was still highly increased(P<0 .05) ,but sOB‐R was no significant difference (P>0 .05) .The level of LEP in the postmenopausal breast cancer patients were highly increased than menopause patients (P>0 .05) ,and the expression of LEP in cancer group were signifi‐cant higher than two control groups by both postmenopausal and menopause (P>0 .05) .The result suggested the serum level of LEP and FLI are associated with pTNM stages and lymph node metastases (P<0 .05) ,and elevated level of LEP in postmenopausal patients had differences in pTNM stages and lymph node metastases (P< 0 .05) .Conclusion The serum LEP level and the FLI may be potential indicators to evaluate the prognosis of the patient with breast cancer .The serum LEP may promoted the process of the postmenopausal patients of breast cancer .