CAJ | 학술논문

[目的]探讨胰岛素信号通路与肿瘤风险的相关性，并明晰相关机制。[方法]本文总结近年来开展的体内试验和体外试验，从胰岛素信号通路激活、细胞内信号转导机制及胰岛素信号通路基因水平三方面进行阐述。[结果]胰岛素及胰岛素类似物可与胰岛素受体、胰岛素样生长因子受体、杂合受体结合，激活细胞内丝裂原活化蛋白激酶信号通路、磷脂酰肌醇3激酶信号通路及可能存在的其他信号通路，促使细胞有丝分裂、增殖及抗细胞凋亡，增加肿瘤生成、癌变、转移的风险。然而，胰岛素信号通路中信号分子的基因多态性却并不一定增加肿瘤风险。[结论]体外研究表明胰岛素信号通路与肿瘤风险相关。而胰岛素及其类似物在人体内环境中是否同样能增加肿瘤风险，值得更深一步的研究。
[목적]탐토이도소신호통로여종류풍험적상관성，병명석상관궤제。[방법]본문총결근년래개전적체내시험화체외시험，종이도소신호통로격활、세포내신호전도궤제급이도소신호통로기인수평삼방면진행천술。[결과]이도소급이도소유사물가여이도소수체、이도소양생장인자수체、잡합수체결합，격활세포내사렬원활화단백격매신호통로、린지선기순3격매신호통로급가능존재적기타신호통로，촉사세포유사분렬、증식급항세포조망，증가종류생성、암변、전이적풍험。연이，이도소신호통로중신호분자적기인다태성각병불일정증가종류풍험。[결론]체외연구표명이도소신호통로여종류풍험상관。이이도소급기유사물재인체내배경중시부동양능증가종류풍험，치득경심일보적연구。
Objective]The article was to investigate the relationship between insulin signaling pathway and cancer risks and clarify the related mechanism. [Methods]Recent years experiments in vivo and in vitro, were summarized by three aspects about the insulin signaling pathway activation, intracellular signal transduction mechanisms and the genetics of insulin signaling pathway.[Result]Insulin and insulin analogs can bind to insulin receptor, insulin-like growth factor receptor, and hybrid receptor, and activate intracellular signal transduction pathways downstream, such as mitogen-activated protein kinase cascade, phosphatidylinositol 3-kinasepathway and other pathways that may exist, to promote mitosis, proliferation and anti-apoptosis, consequently increasing risks of tumor growth and development ,and cancer metastasis. Whereas, single-nucleotide polymorphisms of insulin signaling pathway related genes do not necessarily increase cancer risks. [Conclusion]Vitro studies have confirmed that insulin signaling pathway is associated with cancer risk. Whether the insulin and its analogs can actually increase cancer risks in human body, is worthy of further research.