CAJ | 학술논문

目的：研究重型颅脑损伤患者肠外营养致高血糖对血清热休克蛋白27（HSP27）抗体表达的影响。方法：将2013年9月到2014年12月我科ICU收治的重型颅脑损伤行肠外营养致高血糖的31例患者随机分为胰岛素强化治疗组（IIT组，n＝16）及常规血糖控制组（CGC 组，n＝16），其至少50％的估计能量需要量（EER）由肠外营养获得。比较两组入ICU时、第7 d 和第14 d 血清抗HSP27抗体浓度。结果：IIT组血清HSP27抗体浓度第14d 较GCG组明显下降（P ＜0．05）。结论：胰岛素强化治疗可通过降低血清中HSP27抗体而减轻接受肠外营养的重型颅脑损伤患者的神经元应激。
목적：연구중형로뇌손상환자장외영양치고혈당대혈청열휴극단백27（HSP27）항체표체적영향。방법：장2013년9월도2014년12월아과ICU수치적중형로뇌손상행장외영양치고혈당적31례환자수궤분위이도소강화치료조（IIT조，n＝16）급상규혈당공제조（CGC 조，n＝16），기지소50％적고계능량수요량（EER）유장외영양획득。비교량조입ICU시、제7 d 화제14 d 혈청항HSP27항체농도。결과：IIT조혈청HSP27항체농도제14d 교GCG조명현하강（P ＜0．05）。결론：이도소강화치료가통과강저혈청중HSP27항체이감경접수장외영양적중형로뇌손상환자적신경원응격。
Objective:To study the expressions effect on Anti-HSP27 of serum in patients with traumatic brain injury received parenteral nutrition (PN). Methods: 31 patients with traumatic brain injury received PN and caused hyperglycemia in the ICU were randomly divided into intensive insulin treatment (IIT) group(n=16) and conventional glucose control (CGC) group (n=15) treated IIT and CGC respectively from Sep 2013 to Dec 2104. The cases received at least 50% of their estimated daily energy requirements parenterally. Serum anti HSP27 antibody concentration was compared at baseline,day 7 and day 14 between the two groups. Results: On day 14,serum anti HSP27 antibody concentration in the IIT group was a significantly shorter than that in the GCG group (P<0.05). Conclusion:Intensive insulin therapy can reduce stress by reducing anti- HSP27 in serum in traumatic brain injury patients received PN.